Soy food consumption and lung cancer risk: a meta-analysis using a common measure across studies.
Soy food consumption and lung cancer risk: a meta-analysis using a common measure across studies.
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DOI：
10.1080/01635581.2013.795983
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Wu SH;Liu Z
一项已发表的荟萃分析通过使用每个研究中大豆或异黄酮类摄入量最高和最低类别的特定研究的优势比(OR)或相对风险(RR)来合并个别研究，但在研究/人群之间进行肺癌风险比较应该是有问题的，因为不同研究/人群的分位数如此不同。因此，我们进行了一项荟萃分析，以探索估计每日大豆蛋白摄入量(以克为单位)与肺癌风险之间的关系。我们提取了OR或RR和95%的可信区间(CI)，将它们转换为每天大豆蛋白摄入量的估计值，并使用来自11项流行病学研究的固定或随机效应模型将它们合并在一起。总体而言，每日大豆蛋白摄入量与肺癌风险之间的负相关关系在统计学上接近显著(OR=0.98，95%CI=0.96-1.00)；在非吸烟者中，这种负相关关系在统计学上显著(0.96；0.93-0.99)，并且强于吸烟者(P为Difference<；0.05)。性别、参与者来源、研究设计和大豆摄入量类型之间的关联没有统计学意义。这项研究表明，每天摄入以克为单位的大豆蛋白可以边缘降低患肺癌的风险，而不吸烟的人患肺癌的风险则呈显著的负相关。
A published meta-analysis pooled individual studies by using the study-specific odds ratio (OR) or relative risk (RR) for the highest versus lowest category of soy or isoflavone intake from each study, but it should be problematic to make comparison between studies/populations for lung cancer risk as the quantiles are so different from different studies/populations. Therefore, we conducted a meta-analysis to explore the association between exposure of estimated daily soy protein intake in grams and lung cancer risk. We extracted ORs or RRs and 95% confidence intervals (CIs), converted them to the estimated ones for daily soy protein intake and pooled them using fixed or random effects models from 11 epidemiologic studies. Overall, the inverse association between daily grams of soy protein intake and risk of lung cancer was borderline statistically significant (OR=0.98, 95% CI=0.96 to 1.00); the inverse association was statistically significant in nonsmokers (0.96; 0.93–0.99) and stronger than in smokers (P for difference<0.05). No statistical significance for the associations was observed between genders, the origin of the participants, study design and types of soy intake. This study suggests a borderline reduction in risk of lung cancer with daily soy protein intake in grams, and a significant inverse association in nonsmokers.
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DOI：
10.1158/1055-9965.epi-08-0892
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
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通讯作者：
Yu MC
影响因子：
2
作者：
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Ambuehl, Mathias
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
4.2
作者：
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通讯作者：
Scambia, Giovanni
影响因子：
2.9
作者：
Menon, LG;Kuttan, R;Kuttan, G
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Kuttan, G