The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study.
The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study.
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DOI：
10.1038/s41598-020-76382-x
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发表时间：
2020-11-24
影响因子：
4.6
通讯作者：
Crosson BA
中科院分区：
文献类型：
--
作者：
Krishnamurthy LC;Champion GN;McGregor KM;Krishnamurthy V;Turabi A;Roberts SR;Nocera JR;Borich MR;Rodriguez AD;Belagaje SR;Harrington RM;Harris-Love ML;Harnish SM;Drucker JH;Benjamin M;Meadows ML;Seeds L;Zlatar ZZ;Sudhyadhom A;Butler AJ;Garcia A;Patten C;Trinastic J;Kautz SA;Gregory C;Crosson BA
最近的中风研究表明，在急性和亚急性阶段中风后，同侧病变丘脑纵向显着减少。然而，中风慢性阶段的其他考虑因素需要探索，包括中风后的时间、性别、皮质内体积、衰老和病变体积，以更好地表征皮质梗塞后丘脑的差异。这项横断面回顾性研究对 69 名慢性卒中受试者（35-92 岁）的解剖 MRI 数据中的同侧和对侧丘脑体积进行了量化，并将丘脑体积与中风发生后的时间、性别、皮质内体积、年龄和病变体积相关联。同侧病变丘脑体积显着小于对侧病变丘脑体积（t(68) = 13.89，p < 0.0001）。在同侧丘脑中，对皮质内体积（t（68） = 2.76，p = 0.008）、年龄（t（68） = 2.47，p = 0.02）、病变体积（t（68） = − 3.54， p = 0.0008），并确定年龄*中风以来的时间（t（68） = 2.46，p = 0.02）。在对侧丘脑中，发现皮质内体积（t(68) = 3.2，p = 0.002）和年龄（t = − 3.17，p = 0.002）有显着影响。临床因素年龄和皮质内体积影响同侧和对侧丘脑体积，病变体积影响同侧丘脑。由于这项研究的横截面性质，需要进行额外的研究来了解神经回路的差异以及中风后对容量的影响。
Recent stroke studies have shown that the ipsi-lesional thalamus longitudinally and significantly decreases after stroke in the acute and subacute stages. However, additional considerations in the chronic stages of stroke require exploration including time since stroke, gender, intracortical volume, aging, and lesion volume to better characterize thalamic differences after cortical infarct. This cross-sectional retrospective study quantified the ipsilesional and contralesional thalamus volume from 69 chronic stroke subjects’ anatomical MRI data (age 35–92) and related the thalamus volume to time since stroke, gender, intracortical volume, age, and lesion volume. The ipsi-lesional thalamus volume was significantly smaller than the contra-lesional thalamus volume (t(68) = 13.89, p < 0.0001). In the ipsilesional thalamus, significant effect for intracortical volume (t(68) = 2.76, p = 0.008), age (t(68) = 2.47, p = 0.02), lesion volume (t(68) = − 3.54, p = 0.0008), and age*time since stroke (t(68) = 2.46, p = 0.02) were identified. In the contralesional thalamus, significant effect for intracortical volume (t(68) = 3.2, p = 0.002) and age (t = − 3.17, p = 0.002) were identified. Clinical factors age and intracortical volume influence both ipsi- and contralesional thalamus volume and lesion volume influences the ipsilesional thalamus. Due to the cross-sectional nature of this study, additional research is warranted to understand differences in the neural circuitry and subsequent influence on volumetrics after stroke.
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影响因子：
4.8
作者：
Pustina D;Coslett HB;Turkeltaub PE;Tustison N;Schwartz MF;Avants B
通讯作者：
Avants B
影响因子：
16.2
作者：
Corbetta M;Ramsey L;Callejas A;Baldassarre A;Hacker CD;Siegel JS;Astafiev SV;Rengachary J;Zinn K;Lang CE;Connor LT;Fucetola R;Strube M;Carter AR;Shulman GL
通讯作者：
Shulman GL
影响因子：
5.7
作者：
Hughes, Emer J.;Bond, Jacqueline;Svrckova, Patricia;Makropoulos, Antonis;Ball, Gareth;Sharp, David J.;Edwards, A. David;Hajnal, Joeseph V.;Counsell, Serena J.
通讯作者：
Counsell, Serena J.
影响因子：
6.1
作者：
Sandu RE;Buga AM;Uzoni A;Petcu EB;Popa-Wagner A
通讯作者：
Popa-Wagner A
DOI：
10.1093/cercor/bhy109
发表时间：
2018-08-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Ritchie SJ;Cox SR;Shen X;Lombardo MV;Reus LM;Alloza C;Harris MA;Alderson HL;Hunter S;Neilson E;Liewald DCM;Auyeung B;Whalley HC;Lawrie SM;Gale CR;Bastin ME;McIntosh AM;Deary IJ
通讯作者：
Deary IJ