Regional changes in thalamic shape and volume with increasing age.
Regional changes in thalamic shape and volume with increasing age.
复制标题
DOI：
10.1016/j.neuroimage.2012.07.043
复制
发表时间：
2012-11-15
期刊：
影响因子：
5.7
通讯作者：
Counsell, Serena J.
中科院分区：
文献类型：
--
作者：
Hughes, Emer J.;Bond, Jacqueline;Svrckova, Patricia;Makropoulos, Antonis;Ball, Gareth;Sharp, David J.;Edwards, A. David;Hajnal, Joeseph V.;Counsell, Serena J.
随着年龄的增长，丘脑的体积和显微结构发生了显着的变化。丘脑-皮质连接的改变可能导致与衰老相关的认知能力下降。本研究的目的是评估丘脑形状的变化和丘脑区域的体积和扩散率，以检验年龄相关的丘脑变化主要影响丘脑核连接到额叶皮质的假设，通过它们与特定皮质区域的连接进行分割。采用结构磁共振成像（MRI）和弥散张量成像（DTI），我们评估了86名健康志愿者的丘脑体积和弥散度，中位（范围）年龄44（20-74）岁。区域丘脑微观和宏观结构的变化进行了评估，分割丘脑的基础上连接到额叶，顶叶，颞叶和枕叶皮质和确定的体积和平均扩散率的丘脑预测。进行线性回归分析，以测试年龄增加与（i）标准化丘脑体积，（ii）整个丘脑扩散测量，（iii）丘脑-皮质投射的平均扩散率（MD），和（iv）丘脑-皮质投射的体积之间的关系。我们还评估了丘脑形状的变化，使用顶点分析。我们观察到一个显着的体积减少，并在整个丘脑MD随年龄的增加显着增加。随着年龄的增长，丘脑-额叶投射的体积显着下降，但丘脑-皮质投射到顶叶，颞叶和枕叶皮质的体积和年龄之间没有显着的关系。丘脑形状分析表明，最大的形状变化是在前丘脑，包括前核，腹前核和背内侧核的区域。为了进一步探索这些结果，我们研究了另外两组受试者（一个年轻组和一个老年组，n = 20），这表明丘脑-额叶投射的体积与执行功能评分相关，如Stroop测试所评估的。这些数据表明，额叶丘脑-皮质单位的萎缩可以解释，至少部分地，注意力障碍，工作记忆和执行功能与年龄增长。
The thalamus undergoes significant volume loss and microstructural change with increasing age. Alterations in thalamo-cortical connectivity may contribute to the decline in cognitive ability associated with aging. The aim of this study was to assess changes in thalamic shape and in the volume and diffusivity of thalamic regions parcellated by their connectivity to specific cortical regions in order to test the hypothesis age related thalamic change primarily affects thalamic nuclei connecting to the frontal cortex. Using structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), we assessed thalamic volume and diffusivity in 86 healthy volunteers, median (range) age 44 (20–74) years. Regional thalamic micro and macro structural changes were assessed by segmenting the thalamus based on connectivity to the frontal, parietal, temporal and occipital cortices and determining the volumes and mean diffusivity of the thalamic projections. Linear regression analysis was performed to test the relationship between increasing age and (i) normalised thalamic volume, (ii) whole thalamus diffusion measures, (iii) mean diffusivity (MD) of the thalamo-cortical projections, and (iv) volumes of the thalamo-cortical projections. We also assessed thalamic shape change using vertex analysis. We observed a significant reduction in the volume and a significant increase in MD of the whole thalamus with increasing age. The volume of the thalamo-frontal projections decreased significantly with increasing age, however there was no significant relationship between the volumes of the thalamo-cortical projections to the parietal, temporal, and occipital cortex and age. Thalamic shape analysis showed that the greatest shape change was in the anterior thalamus, incorporating regions containing the anterior nucleus, the ventroanterior nucleus and the dorsomedial nucleus. To explore these results further we studied two additional groups of subjects (a younger and an older aged group, n = 20), which showed that the volume of the thalamo-frontal projections was correlated to executive functions scores, as assessed by the Stroop test. These data suggest that atrophy of the frontal thalamo-cortical unit may explain, at least in part, disorders of attention, working memory and executive function associated with increasing age.
登录
查看更多内容
影响因子：
3.7
作者：
Johansen-Berg, H;Behrens, TEJ;Matthews, PM
通讯作者：
Matthews, PM
影响因子：
5.7
作者：
Giorgio, Antonio;Santelli, Luca;Tomassini, Valentina;Bosnell, Rose;Smith, Steve;De Stefano, Nicola;Johansen-Berg, Heidi
通讯作者：
Johansen-Berg, Heidi
影响因子：
4.2
作者：
Cardenas, V. A.;Chao, L. L.;Studholme, C.;Yaffe, K.;Miller, B. L.;Madison, C.;Buckley, S. T.;Mungas, D.;Schuff, N.;Weiner, M. W.
通讯作者：
Weiner, M. W.
影响因子：
1.8
作者：
Channon, S
通讯作者：
Channon, S
影响因子：
5.7
作者：
Patenaude, Brian;Smith, Stephen M.;Kennedy, David N.;Jenkinson, Mark
通讯作者：
Jenkinson, Mark