Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants.
Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants.
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DOI：
10.1093/cercor/bhy109
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发表时间：
2018-08-01
期刊：
影响因子：
--
通讯作者：
Deary IJ
中科院分区：
文献类型：
--
作者：
Ritchie SJ;Cox SR;Shen X;Lombardo MV;Reus LM;Alloza C;Harris MA;Alderson HL;Hunter S;Neilson E;Liewald DCM;Auyeung B;Whalley HC;Lawrie SM;Gale CR;Bastin ME;McIntosh AM;Deary IJ
人类大脑中的性别差异之所以令人感兴趣，原因有很多：例如，在观察到的精神疾病患病率方面存在性别差异，以及大脑差异可能有助于解释的一些心理特征。我们报告了人类大脑结构和功能性别差异的最大单样本研究（2750名女性，2466名男性参与者;平均年龄61.7岁，范围44-77岁）。男性有较高的原始体积，原始表面积，和白色物质分数各向异性;女性有较高的原始皮质厚度和较高的白色物质道的复杂性。性别之间存在相当大的分布重叠。次区域差异不完全归因于总体积、总表面积、平均皮质厚度或高度的差异。总体而言，男性在原始结构性指标上的差异更大。功能性连接体组织表现出较强的连接男性在单峰感觉运动皮层，和较强的连接女性在默认模式网络。这项大规模的研究为试图了解成人大脑结构和功能性别差异的原因和后果提供了基础。
Sex differences in the human brain are of interest for many reasons: for example, there are sex differences in the observed prevalence of psychiatric disorders and in some psychological traits that brain differences might help to explain. We report the largest single-sample study of structural and functional sex differences in the human brain (2750 female, 2466 male participants; mean age 61.7 years, range 44–77 years). Males had higher raw volumes, raw surface areas, and white matter fractional anisotropy; females had higher raw cortical thickness and higher white matter tract complexity. There was considerable distributional overlap between the sexes. Subregional differences were not fully attributable to differences in total volume, total surface area, mean cortical thickness, or height. There was generally greater male variance across the raw structural measures. Functional connectome organization showed stronger connectivity for males in unimodal sensorimotor cortices, and stronger connectivity for females in the default mode network. This large-scale study provides a foundation for attempts to understand the causes and consequences of sex differences in adult brain structure and function.
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影响因子：
5.7
作者：
Daducci, Alessandro;Canales-Rodriguez, Erick J.;Thiran, Jean-Philippe
通讯作者：
Thiran, Jean-Philippe
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1111/jcpp.12691
发表时间：
2017-06
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Arnett AB;Pennington BF;Peterson RL;Willcutt EG;DeFries JC;Olson RK
通讯作者：
Olson RK
影响因子：
8.2
作者：
Beery AK;Zucker I
通讯作者：
Zucker I
影响因子：
7.6
作者：
Costa, PT;Terracciano, A;McCrae, RR
通讯作者：
McCrae, RR