Systemic inflammation and emotional responses during the COVID-19 pandemic.
Systemic inflammation and emotional responses during the COVID-19 pandemic.
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DOI：
10.1038/s41398-021-01753-5
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发表时间：
2021-12-09
影响因子：
6.8
通讯作者：
Steptoe A
中科院分区：
文献类型：
--
作者：
Hamilton OS;Cadar D;Steptoe A
COVID-19大流行对人群心理健康的影响是全球关注的问题。人们认为炎症过程会导致精神不健康，但尚未调查它们在大流行期间心理困扰经历中的作用。我们测试了这样一种假设，即在大流行前测量的炎症生物标志物（高敏血浆c反应蛋白[CRP]和血浆纤维蛋白原）升高可以积极预测大流行期间抑郁症状的增加。数据分析来自英国老龄化纵向研究（ELSA），在第8（2016/17）或第9（2018/19）波中测量了3574名年龄在50岁至50岁之间的人的CRP和3314名纤维蛋白原。在大流行前（2016-2019年）和大流行期间（2020年6月/ 7月），使用流行病学研究中心抑郁量表（CES-D）的简短版本来测量抑郁症状。在完全调整后，基线CRP浓度较高的参与者在大流行期间出现抑郁症状的几率高出40% （ORadjusted = 1.40, 95% CI 1.12-1.73, p = 0.003）。纤维蛋白原浓度也与大流行期间的抑郁症状相关（or校正= 1.23,95% CI 1.04-1.46, p = 0.019），但在控制了生活方式因素（吸烟状况、饮酒和体育活动）后，这种关联不再显著。在这项大型人群研究中，大流行前1-3年测量的全身性炎症与大流行最初几个月更大的抑郁情绪有关。这一发现与一种假设相一致，即在COVID-19大流行带来的广泛压力下，较高的炎症水平会增加老年人心理健康受损的脆弱性。
The impact of the COVID-19 pandemic on population mental health is of global concern. Inflammatory processes are thought to contribute to mental ill-health, but their role in experiences of psychological distress during the pandemic has not been investigated. We tested the hypothesis that elevated inflammatory biomarkers (high-sensitivity plasma C-reactive protein [CRP] and plasma fibrinogen) measured pre-pandemic would be positively predictive of increased depressive symptoms experienced during the pandemic. Data were analysed from the English Longitudinal Study of Ageing (ELSA), with 3574 individuals aged >50 for CRP and 3314 for fibrinogen measured in waves 8 (2016/17) or 9 (2018/19). Depressive symptoms were measured with a short version of the Centre for Epidemiological Studies Depression Scale (CES-D) pre-pandemic (2016–2019) and during the pandemic (June/July 2020). Participants with higher baseline CRP concentrations had 40% higher odds of developing depressive symptoms during the pandemic (ORadjusted = 1.40, 95% CI 1.12–1.73, p = 0.003) after full adjustment. Fibrinogen concentrations were also associated with depressive symptoms during the pandemic (ORadjusted = 1.23, 95% CI 1.04–1.46, p = 0.019), but this association was no longer significant after controlling for lifestyle factors (smoking status, alcohol consumption and physical activity). In this large population study, systemic inflammation measured 1–3 years pre-pandemic was associated with greater depressed mood during the early months of the pandemic. This finding is consistent with the hypothesis that higher levels of inflammation increase the vulnerability of older people to impaired mental health in the presence of the widespread stress of the COVID-19 pandemic.
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影响因子：
6.8
作者：
Bell JA;Kivimäki M;Bullmore ET;Steptoe A;MRC ImmunoPsychiatry Consortium;Carvalho LA
通讯作者：
Carvalho LA
影响因子：
25.8
作者：
Khandaker GM;Pearson RM;Zammit S;Lewis G;Jones PB
通讯作者：
Jones PB
影响因子：
64.3
作者：
Kola, Lola;Kohrt, Brandon A.;Hanlon, Charlotte;Naslund, John A.;Sikander, Siham;Balaji, Madhumitha;Benjet, Corina;Cheung, Eliza Yee Lai;Eaton, Julian;Gonsalves, Pattie;Hailemariam, Maji;Luitel, Nagendra P.;Machado, Daiane B.;Misganaw, Eleni;Omigbodun, Olayinka;Roberts, Tessa;Salisbury, Tatiana Taylor;Shidhaye, Rahul;Sunkel, Charlene;Ugo, Victor;van Rensburg, Andre Janse;Gureje, Oye;Pathare, Soumitra;Saxena, Shekhar;Thornicroft, Graham;Patel, Vikram
通讯作者：
Patel, Vikram
影响因子：
0.9
作者：
Ahmed, Taha;Lodhi, Samra Haroon;Shah, Gautam V.
通讯作者：
Shah, Gautam V.
影响因子：
6.6
作者：
Daly, Michael;Sutin, Angelina R.;Robinson, Eric
通讯作者：
Robinson, Eric