MICROBIAL RESISTANCE TO ANTIBIOTICS An Evolving and Persistent Problem

MICROBIAL RESISTANCE TO ANTIBIOTICS An Evolving and Persistent Problem
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微生物对抗生素的耐药性是一个不断发展且持续存在的问题

DOI:
10.1016/s0140-6736(82)91701-9
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发表时间:
1982
期刊:
The Lancet
影响因子:
--
通讯作者:
StuartB. Levy
StuartB. Levy
中科院分区:
--
文献类型:
--
作者:
StuartB. Levy

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图1-抗生素耐药基因的遗传交换。抗生素耐药基因可以通过噬菌体(A)和质粒(B)转移到细菌宿主中,如果这些基因位于转座子上,它们可以从进入载体转移到宿主染色体或驻留菌体。在质粒转移的情况下,复制的增殖体将1个拷贝捐赠给新的受体细胞,而供体保留自己的拷贝(B.小组1和2)。如果进入的质粒不稳定,转座子可以通过插入驻留的质粒和/或其染色体而在新宿主中稳定下来(B.面板3)。
Fig. 1-Genetic exchange of antibiotic-resistance genes. Antibiotic resistance genes can be transported into bacterial hosts via bacteriophages (A) and plasmids (B) If these genes are on transposons they can be transferred from the entry vector to the host chromosome or to resident plusmid. In the case of plasmid transfer, the replicating plusmid donates 1 copy to the new recipient cell while the donor retains its own copy (B. panel 1 and 2). If the incoming plasmid is unstable, the transpoon can become stabilised in the new host by insertion into the resident plasmid and/or into its chromosome (B. panel 3).
梅毒螺旋体(尼科尔斯)中的质粒 DNA:梅毒细菌对抗生素产生耐药性的潜力。
DOI: 10.1126/science.6264606
发表时间: 1981
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Norgard,MV;Miller,JN
通讯作者: Miller,JN
产生青霉素酶的淋病奈瑟菌感染的流行病学:通过基因型和血清分型进行分析。
DOI: 10.1056/nejm198204223061602
发表时间: 1982
期刊: The New England journal of medicine
影响因子: --
作者:
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