Distinct metabolic effects following short-term exposure of different high-fat diets in male and female mice.
Distinct metabolic effects following short-term exposure of different high-fat diets in male and female mice.
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在雄性和雌性小鼠中不同高脂饮食短期暴露后，明显的代谢作用。
DOI：
10.1507/endocrj.ej13-0455
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发表时间：
2014
影响因子：
2
通讯作者：
Shi H
中科院分区：
文献类型：
--
作者：
Senthil Kumar SP;Shen M;Spicer EG;Goudjo-Ako AJ;Stumph JD;Zhang J;Shi H
肥胖相关的肝脏脂肪堆积和慢性低度炎症导致代谢缺陷。饱和脂肪酸(SFA)是发生代谢性疾病的危险因素，而不饱和脂肪酸(UFA)被认为是预防代谢性疾病的危险因素。在新陈代谢的调节上存在性别差异。我们测试了一种假设，即高SFA、单不饱和脂肪酸(MUFA)或多不饱和脂肪酸(PUFA)的饮食具有早期的、性别不同的影响，这些影响对脂肪肝和胰岛素抵抗等长期代谢障碍有不同的贡献。比较喂饲低脂饲料、高脂SFA、MUFA和PUFA的雄性和雌性小鼠的体内和脂肪质量、循环瘦素和血糖水平、血脂谱、肝脂蓄积、脂代谢和低度炎症相关基因的表达水平以及组织胰岛素敏感性等代谢变化。SFA和MUFA雄性会增加肥胖，与肝脏脂肪堆积增加和脂肪和肌肉组织中的炎症迅速激活有关，而PUFA雄性与食物雄性相比没有表现出脂肪堆积或组织炎症。所有SFA和UFA男性均表现为组织胰岛素抵抗。相比之下，女性高脂饮食组的肝脏脂肪含量正常，并保持组织对胰岛素的敏感性，没有表现出组织炎症。因此，在代谢功能障碍发生的早期阶段存在性别差异。多不饱和脂肪酸，而不是多不饱和脂肪酸，在预防肥胖、高脂血症、脂肪肝和低度炎症方面的益处得到证实。然而，MUFA和PUFA在维持男性组织胰岛素敏感性方面的益处受到质疑。
Obesity-associated hepatic lipid accumulation and chronic low-grade inflammation lead to metabolic defects. Saturated fatty acids (SFA) are a risk factor for, whereas unsaturated fatty acids (UFA) are thought to be protective against, developing metabolic diseases. Sex differences exist in the regulation of metabolism. We tested the hypothesis that diets high in SFA, mono-UFA (MUFA), or poly-UFA (PUFA) had early, sex-distinct effects that differentially contribute to long-term metabolic disturbance such as fatty liver and insulin resistance. Metabolic changes including body and fat mass, circulating leptin and glucose levels, plasma lipid profile, hepatic lipid accumulation, expression levels of genes related to lipid metabolism and low-grade inflammation, and tissue insulin sensitivity were compared between male and female mice fed with a low-fat chow, or high-fat SFA, MUFA, or PUFA for a short period of four days. SFA and MUFA males increased adiposity associated with increased liver lipid accumulation and rapid activation of inflammation in adipose and muscle tissues, whereas PUFA males did not show lipid accumulation or tissue inflammation compared to chow males. All SFA and UFA males displayed tissue insulin resistance. In contrast, female high-fat diet groups had normal liver lipid content and maintained tissue insulin sensitivity without showing tissue inflammation. Therefore, sex differences existed during early phase of development of metabolic dysfunction. The beneficial effects of PUFA, but not MUFA, were corroborated in protection of obesity, hyperlipidemia, fatty liver, and low-grade inflammation. The benefit of MUFA and PUFA in maintaining tissue insulin sensitivity in males, however, was questioned.
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DOI：
10.1016/j.ecl.2008.09.002
发表时间：
2008-12
影响因子：
4.5
作者：
Lara-Castro, Cristina;Garvey, W. Timothy
通讯作者：
Garvey, W. Timothy
影响因子：
7.7
作者：
Lee YS;Li P;Huh JY;Hwang IJ;Lu M;Kim JI;Ham M;Talukdar S;Chen A;Lu WJ;Bandyopadhyay GK;Schwendener R;Olefsky J;Kim JB
通讯作者：
Kim JB
DOI：
10.1161/01.atv.12.8.955
发表时间：
1992-08-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
CLIFTON, PM;NESTEL, PJ
通讯作者：
NESTEL, PJ
影响因子：
7.7
作者：
KRAEGEN, EW;CLARK, PW;STORLIEN, LH
通讯作者：
STORLIEN, LH
DOI：
10.1016/0005-2760(90)90163-r
发表时间：
1990-02-23
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
MAEHIRA, F;MIYAGI, I;EGUCHI, Y
通讯作者：
EGUCHI, Y