Human T lymphotropic virus type II (HTLV-II) infection in a cohort of New York intravenous drug users: an old infection?
Human T lymphotropic virus type II (HTLV-II) infection in a cohort of New York intravenous drug users: an old infection?
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纽约静脉吸毒者群体中的人类 T 淋巴细胞病毒 II 型 (HTLV-II) 感染：旧有感染？
DOI：
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发表时间：
1991
影响因子：
6.4
通讯作者：
G. Friedland
中科院分区：
文献类型：
--
作者：
R. Khabbaz;D. Hartel;M. Lairmore;C. Horsburgh;E. Schoenbaum;B. Roberts;T. M. Hartley;G. Friedland
为了确定静脉吸毒者（IVDUs）中人类嗜T淋巴细胞病毒II型（HTLV-II）感染的危险因素，对纽约美沙酮维持治疗项目中人类免疫缺陷病毒（HIV）感染的纵向研究参与者进行了研究。在270名接受HTLV-I/II检测的参与者中，21名（8%）血清反应阳性。其中，15（71%）有HTLV-II特异性序列的聚合酶链反应（PCR）和1（5%）有HTLV-I和-II特异性序列; 3人与不确定的血清学结果也PCR阳性HTLV-II。HTLV-II感染与年龄较大显著相关，但与性别、种族、社会经济地位、输血史或HIV感染状态无关。自1978年以来的行为因素，如静脉注射毒品的持续时间和频率，共用针头，参观射击场或性伴侣的数量，也与HTLV-II感染无关。这些研究结果与该组中这些危险因素与HIV的相关性形成对比，并表明，在IVDUs中，HTLV-II是一种较古老的地方性感染，其传播效率低于HIV。
To identify risk factors for human T lymphotropic virus type II (HTLV-II) infection in intravenous drug users (IVDUs), participants in a longitudinal study of human immunodeficiency virus (HIV) infection in a New York methadone maintenance program were studied. Of 270 participants tested for HTLV-I/II, 21 (8%) were seropositive. Of those, 15 (71%) had HTLV-II-specific sequences by polymerase chain reaction (PCR) and 1 (5%) had both HTLV-I- and -II-specific sequences; 3 persons with indeterminate serologic results were also PCR-positive for HTLV-II. HTLV-II infection was significantly associated with older age but was not predicted by sex, race, socioeconomic status, transfusion history, or HIV infection status. Behavioral factors since 1978, such as duration and frequency of intravenous drug use, needle sharing, visits to shooting galleries, or number of sex partners, were also not associated with HTLV-II infection. These findings are in contrast with the association of these risk factors with HIV in this group and suggest that, among IVDUs, HTLV-II is an older endemic infection that is less efficiently transmitted than HIV.
人类新 HTLV 相关内源序列的检测和克隆。
影响因子：
14.9
作者：
Perl,A;Rosenblatt,JD;Chen,IS;DiVincenzo,JP;Bever,R;Poiesz,BJ;Abraham,GN
通讯作者：
Abraham,GN
影响因子：
158.5
作者：
SELWYN, PA;HARTEL, D;FRIEDLAND, GH
通讯作者：
FRIEDLAND, GH
静脉吸毒者感染人类免疫缺陷病毒的危险因素。
DOI：
10.1056/nejm198909283211306
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
--
作者：
Schoenbaum,EE;Hartel,D;Selwyn,PA;Klein,RS;Davenny,K;Rogers,M;Feiner,C;Friedland,G
通讯作者：
Friedland,G