Postnatal growth of intrinsic connections in mouse barrel cortex
Postnatal growth of intrinsic connections in mouse barrel cortex
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小鼠桶状皮层内在连接的出生后生长
DOI：
--
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
T. Woolsey
中科院分区：
文献类型：
--
作者：
B. Miller;Nicquet M. J. Blake;J. Erinjeri;Chet E. Reistad;Tesa Sexton;Phillip Admire;T. Woolsey
令人惊讶的是，人们对大脑皮层功能区内连接的发展知之甚少。我们研究了出生后第二周和第三周小鼠桶状皮质中连接的出生后生长情况，这一时期恰好发生在桶第一形状之后的快速突触形成时期。桶是躯体感觉皮层第四层的一组神经元，是皮质柱的一部分。每个晶须/桶柱在解剖上和功能上连接到对侧表面上的同源晶须。在出生后第8天(P8；P0是出生日期)到成年的小鼠身上，用神经元示踪剂生物素化的葡聚糖胺标记了径向皮质神经元群。对逆标神经元在不同板层的空间分布进行了分析。第四层中的桶地图被用作模板，以比较来自不同动物的定量数据，并解释在开发过程中桶和桶田大小的实质性变化。内在投射1)支配3周龄以下的桶皮质内越来越远的靶点；2)3周后继续在靶体内形成，有效地加强了现有的联系；3)遵循特定层的生长时间表；4)将第4层中更远的桶柱与优先在桶侧发现的神经元和桶之间的隔膜联系起来；5)在桶柱之间的最短距离上形成。这些数据表明，小鼠桶状皮质中的内在联系是通过逐渐增加神经元联系而不是通过建立初步联系来发展的。我们描述了发育过程中连接性的统计显著变化，这些变化可用于在各种实验扰动后对连接的发展进行建模和评估，例如对环境和/或基因组的影响。J.Comp.神经。436：17-31,2001。©2001 Wiley-Liss公司
Surprisingly little is known about the development of connections within a functional area of the cerebral cortex. We examined the postnatal growth of connections in mouse barrel cortex during the second and third weeks after birth, coinciding with the period of rapid synaptogenesis that occurs just after the barrels first form. A barrel is a group of neurons in layer 4 of somatosensory cortex that is part of a cortical column. Each whisker/barrel column is linked anatomically and functionally to a homotopic whisker on the contralateral face. Radial groups of cortical neurons were labeled with the neuronal tracer biotinylated dextran amine in mice ranging in age from postnatal day 8 (P8; P0 is the date of birth) to adulthood. The spatial distributions of retrogradely labeled neurons in different laminae were analyzed. The barrel map in layer 4 was used as a template to compare quantitative data from different animals and to account for substantial changes in barrel and barrel field size during development. Intrinsic projections 1) innervate increasingly more distant targets within barrel cortex up to 3 weeks of age; 2) continue to form in targets after 3 weeks, effectively strengthening existing connections; 3) follow a timetable for growth that is layer‐specific; 4) link more distant barrel columns in layer 4 from neurons that are found preferentially in the barrel side and the septa between barrels; and 5) form over the shortest distances between the barrel columns. These data indicate that intrinsic connections in mouse barrel cortex develop by the progressive addition of neuronal connections rather than by sculpting preliminary connections. We describe statistically significant changes in connectivity during development that may be applied to model and assess the development of connections after a variety of experimental perturbations, such as to the environment and/or the genome. J. Comp. Neurol. 436:17–31, 2001. © 2001 Wiley‐Liss, Inc.
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影响因子：
3.7
作者：
Senft, Stephen L.;Woolsey, Thomas A.
通讯作者：
Woolsey, Thomas A.
影响因子：
0.9
作者：
Nicolelis,MA;Chapin,JK;Lin,CS
通讯作者：
Lin,CS
早期传入神经阻滞后，皮质局部回路轴突并不成熟。
DOI：
10.1073/pnas.89.5.1832
发表时间：
1992
影响因子：
11.1
作者：
McCasland,JS;Bernardo,KL;Probst,KL;Woolsey,TA
通讯作者：
Woolsey,TA
影响因子：
2.5
作者：
ARMSTRONGJAMES, M;FOX, K;DASGUPTA, A
通讯作者：
DASGUPTA, A
DOI：
10.1073/pnas.88.3.745
发表时间：
1991-02-01
影响因子：
11.1
作者：
CALLAWAY, EM;KATZ, LC
通讯作者：
KATZ, LC