The Temporal Dynamics of Spontaneous Emotional Brain States and Their Implications for Mental Health.

The Temporal Dynamics of Spontaneous Emotional Brain States and Their Implications for Mental Health.
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DOI:
10.1162/jocn_a_01787
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发表时间:
2022-03-31
影响因子:
3.2
通讯作者:
LaBar, Kevin S.
LaBar, Kevin S.
中科院分区:
医学3区
文献类型:
--
作者:
Kragel, Philip A.;Hariri, Ahmad R.;LaBar, Kevin S.

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在日常走神过程中,时间过程在阐述和调节情绪反应中起着重要作用。然而,目前尚不清楚人类大脑是否在休息时可靠地在多种情绪状态之间转换,以及精神病理学如何改变这些影响动态。在这里,我们结合模式分类和随机过程建模来研究指示六种情绪(愤怒、满足、恐惧、快乐、悲伤、惊讶)和中性状态的自发脑活动的计时学。我们对静息状态功能磁共振成像期间这些大脑状态的动态出现进行了建模,并在两个人群队列中验证了结果-杜克大学神经遗传学研究和内森·克莱恩研究所罗克兰样本。我们的发现表明,内在的情绪脑动态被有效地描述为一个离散的时间马尔可夫过程,情感状态围绕着一个中性中枢组织。在患有精神病的人中,这个网络中枢的中心地位被打乱了,他们的大脑状态转换表现出更大的惰性,不太频繁地从情绪状态重置到中性状态。这些结果为大脑如何发出自发情绪的信号,以及它们的时间动态变化如何有助于损害心理健康提供了新的见解。
Temporal processes play an important role in elaborating and regulating emotional responding during routine mind wandering. However, it is unknown whether the human brain reliably transitions among multiple emotional states at rest, and how psychopathology alters these affect dynamics. Here we combined pattern classification and stochastic process modeling to investigate the chronometry of spontaneous brain activity indicative of six emotions (anger, contentment, fear, happiness, sadness, surprise) and a neutral state. We modeled the dynamic emergence of these brain states during resting-state functional magnetic resonance imaging and validated the results across two population cohorts – the Duke Neurogenetics Study and the Nathan Kline Institute Rockland Sample. Our findings indicate that intrinsic emotional brain dynamics are effectively characterized as a discrete time Markov process, with affective states organized around a neutral hub. The centrality of this network hub is disrupted in individuals with psychopathology, whose brain state transitions exhibit greater inertia and less frequent resetting from emotional to neutral states. These results yield novel insights into how the brain signals spontaneous emotions and how alterations in their temporal dynamics contribute to compromised mental health.
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