Serum amylase in bulimia nervosa and purging disorder: differentiating the association with binge eating versus purging behavior.
Serum amylase in bulimia nervosa and purging disorder: differentiating the association with binge eating versus purging behavior.
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DOI：
10.1016/j.physbeh.2011.06.025
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发表时间：
2011-10-24
影响因子：
2.9
通讯作者：
Keel, Pamela K.
中科院分区：
文献类型：
--
作者：
Wolfe, Barbara E.;Jimerson, David C.;Smith, Adrian;Keel, Pamela K.
神经性贪食症（BN）患者血清淀粉酶水平升高，与唾液腺增大和部分患者自我诱发呕吐相关，可能是症状严重程度的标志。本研究的目的是评估BN的血清高淀粉酶血症是否与涉及大量食物消耗的暴饮暴食事件或与清除行为更密切相关。参与者包括BN女性（n=26）;“净化障碍”（PD）女性，EDNOS的一种亚型，其特征是在没有客观的大暴食发作的情况下反复净化（n=14）;和健康的非进食障碍女性对照（n=32）。各组之间的年龄或体重指数（BMI）没有显著差异。临床组报告了相似的自我诱发呕吐行为频率，并且没有精神药物。禁食过夜后采集血清样品，并通过酶法测定α-淀粉酶。与PD（44.7 ± 17.1 IU/L，p <0.02）和对照组（49.3 ± 15.8，p <0.05）相比，BN中的血清淀粉酶水平显著升高（60.7 ± 25.4国际单位[IU]/升，平均值± sd）。这些发现提供的证据表明，这是反复暴饮暴食，涉及大量的食物，而不是自我诱导的呕吐，这有助于BN血清淀粉酶值升高。
Elevated serum amylase levels in bulimia nervosa (BN), associated with increased salivary gland size and self-induced vomiting in some patients, provide a possible marker of symptom severity. The goal of this study was to assess whether serum hyperamylasemia in BN is more closely associated with binge eating episodes involving consumption of large amounts of food or with purging behavior. Participants included women with BN (n=26); women with “purging disorder” (PD), a subtype of EDNOS characterized by recurrent purging in the absence of objectively large binge eating episodes (n=14); and healthy non-eating disorder female controls (n=32). There were no significant differences in age or body mass index (BMI) across groups. The clinical groups reported similar frequency of self-induced vomiting behavior and were free of psychotropic medications. Serum samples were obtained after overnight fast and were assayed for alpha-amylase by enzymatic method. Serum amylase levels were significantly elevated in BN (60.7 ± 25.4 international units [IU]/liter, mean ± sd) in comparison to PD (44.7 ± 17.1 IU/L, p < 02) and to Controls (49.3 ± 15.8, p < .05). These findings provide evidence to suggest that it is recurrent binge eating involving large amounts of food, rather than self-induced vomiting, which contributes to elevated serum amylase values in BN.
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影响因子：
4.8
作者：
Tanaka, M;Naruo, T;Nozoe, S
通讯作者：
Nozoe, S
影响因子：
--
作者：
Keel, Pamela K.;Wolfe, Barbara E.;Jimerson, David C.
通讯作者：
Jimerson, David C.
影响因子：
6.9
作者：
MITCHELL, JE;PYLE, RL;LENTZ, R
通讯作者：
LENTZ, R
影响因子：
4.7
作者：
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通讯作者：
MESSICK, S
影响因子：
10.6
作者：
Metzger, ED;Levine, JM;Jimerson, DC
通讯作者：
Jimerson, DC