Tumor-on-a-chip: from bioinspired design to biomedical application.
Tumor-on-a-chip: from bioinspired design to biomedical application.
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肿瘤芯片：从仿生设计到生物医学应用
DOI：
10.1038/s41378-021-00277-8
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发表时间：
2021
影响因子：
7.9
通讯作者：
Hu N
中科院分区：
文献类型：
--
作者：
Liu X;Fang J;Huang S;Wu X;Xie X;Wang J;Liu F;Zhang M;Peng Z;Hu N
癌症是人类死亡的主要原因之一，尽管在探索癌症生物学和开发抗癌疗法方面付出了巨大努力。癌症研究的主要挑战是建立有效的肿瘤体外微环境，探索筛选抗癌药物的有效方法，以揭示癌症的本质并开发治疗方法。肿瘤微环境具有人类特异性的生物物理和生物化学因素，这些因素难以在常规的体外平面细胞模型和体内动物模型中重现。因此，模型的局限性阻碍了基础研究成果向临床应用的转化。本文详细介绍了肿瘤芯片在肿瘤生物学研究、医学评估和生物医学应用方面的最新进展。集成3D细胞培养、微流体技术和组织工程的新兴肿瘤芯片平台已经成功地模拟了体内肿瘤微环境的关键结构和功能特征。本文对肿瘤芯片平台在肿瘤生物学研究和生物医学应用中的最新进展进行了详细的介绍和分析。这篇综述对于进一步了解肿瘤演变过程的机制、筛选抗癌药物和开发癌症治疗方法具有重要价值，并讨论了预测药物筛选和癌症治疗的挑战和潜在机会。
Cancer is one of the leading causes of human death, despite enormous efforts to explore cancer biology and develop anticancer therapies. The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop treatments. The tumor microenvironment possesses human-specific biophysical and biochemical factors that are difficult to recapitulate in conventional in vitro planar cell models and in vivo animal models. Therefore, model limitations have hindered the translation of basic research findings to clinical applications. In this review, we introduce the recent progress in tumor-on-a-chip devices for cancer biology research, medicine assessment, and biomedical applications in detail. The emerging tumor-on-a-chip platforms integrating 3D cell culture, microfluidic technology, and tissue engineering have successfully mimicked the pivotal structural and functional characteristics of the in vivo tumor microenvironment. The recent advances in tumor-on-a-chip platforms for cancer biology studies and biomedical applications are detailed and analyzed in this review. This review should be valuable for further understanding the mechanisms of the tumor evolution process, screening anticancer drugs, and developing cancer therapies, and it addresses the challenges and potential opportunities in predicting drug screening and cancer treatment.
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DOI：
10.2147/dddt.s49584
发表时间：
2014
期刊：
Drug design, development and therapy
影响因子：
--
作者：
Cekanova M;Rathore K
通讯作者：
Rathore K
DOI：
10.1016/j.mattod.2015.05.002
发表时间：
2015-12
期刊：
Materials today (Kidlington, England)
影响因子：
--
作者：
Asghar W;El Assal R;Shafiee H;Pitteri S;Paulmurugan R;Demirci U
通讯作者：
Demirci U
影响因子：
13.6
作者：
Carvalho, M. R.;Barata, D.;Habibovic, P.
通讯作者：
Habibovic, P.
影响因子：
3.7
作者：
Beckwitt CH;Clark AM;Wheeler S;Taylor DL;Stolz DB;Griffith L;Wells A
通讯作者：
Wells A
影响因子：
3.2
作者：
Brown, Jacquelyn A.;Pensabene, Virginia;Wikswo, John P.
通讯作者：
Wikswo, John P.