Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance.
Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance.
复制标题
铜绿假单胞菌的毒力因子和抗电力策略以对抗其耐药性。
DOI：
10.3389/fcimb.2022.926758
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
铜绿假单胞菌是一种条件致病菌，可引起重症和免疫功能低下患者的医院感染。它广泛传播于环境中，尤其是在医院，由于耐药菌株的不断出现，已成为对人类健康的主要威胁。铜绿假单胞菌利用多种耐药机制，导致慢性感染难以根除。多种毒力因子负责细菌的黏附和定植、宿主免疫抑制和免疫逃逸，在铜绿假单胞菌的致病过程中发挥着重要作用。因此，旨在降低毒力同时防止细菌最终被免疫系统消除的抗毒力疗法，或联合疗法，与传统的抗生素疗法相比具有显著的优势，因为前者对铜绿假单胞菌施加的选择压力最小，因此不太可能产生耐药性。本文就铜绿假单胞菌的毒力因子、致病作用以及治疗铜绿假单胞菌感染的抗毒力药物研究进展作一综述。
Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in severely ill and immunocompromised patients. Ubiquitously disseminated in the environment, especially in hospitals, it has become a major threat to human health due to the constant emergence of drug-resistant strains. Multiple resistance mechanisms are exploited by P. aeruginosa, which usually result in chronic infections difficult to eradicate. Diverse virulence factors responsible for bacterial adhesion and colonization, host immune suppression, and immune escape, play important roles in the pathogenic process of P. aeruginosa. As such, antivirulence treatment that aims at reducing virulence while sparing the bacterium for its eventual elimination by the immune system, or combination therapies, has significant advantages over traditional antibiotic therapy, as the former imposes minimal selective pressure on P. aeruginosa, thus less likely to induce drug resistance. In this review, we will discuss the virulence factors of P. aeruginosa, their pathogenic roles, and recent advances in antivirulence drug discovery for the treatment of P. aeruginosa infections.
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