Gene Polymorphisms and Biological Effects of Vitamin D Receptor on Nonalcoholic Fatty Liver Disease Development and Progression.
Gene Polymorphisms and Biological Effects of Vitamin D Receptor on Nonalcoholic Fatty Liver Disease Development and Progression.
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维生素D受体基因多态性及其在非酒精性脂肪性肝病发生发展中的生物学作用
DOI：
10.3390/ijms24098288
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发表时间：
2023-05-05
影响因子：
5.6
通讯作者：
Triantos, Christos
中科院分区：
文献类型：
--
作者：
Tourkochristou, Evanthia;Mouzaki, Athanasia;Triantos, Christos
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病，在全球范围内的患病率不断增加。NAFLD发病机制的遗传和分子背景尚不清楚。维生素D/维生素D受体（VDR）轴与NAFLD的发生和进展显著相关。基因多态性可能会影响VDR基因的调控，但其生物学意义仍有待阐明。VDR基因多态性与NAFLD的存在和严重程度相关，因为它们可能影响脂肪组织活性、纤维化和肝细胞癌（HCC）发展的调节。维生素D与肝脏VDR结合以发挥其生物学功能，通过激活VDR转录活性以调节与炎症和纤维化相关的基因表达，或通过VDR介导的Ca 2+通道激活诱导细胞内信号转导。VDR活性对肝脂肪变性具有保护和有害作用，这是NAFLD的特征。维生素D-VDR信号传导可以通过调节免疫反应、脂毒性和纤维化来控制NAFLD的进展。阐明VDR在NAFLD病理生理学中的遗传和分子背景将通过开发VDR激动剂为这种疾病提供新的治疗靶点，其已经在体内显示出有希望的结果。
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with increasing prevalence worldwide. The genetic and molecular background of NAFLD pathogenesis is not yet clear. The vitamin D/vitamin D receptor (VDR) axis is significantly associated with the development and progression of NAFLD. Gene polymorphisms may influence the regulation of the VDR gene, although their biological significance remains to be elucidated. VDR gene polymorphisms are associated with the presence and severity of NAFLD, as they may influence the regulation of adipose tissue activity, fibrosis, and hepatocellular carcinoma (HCC) development. Vitamin D binds to the hepatic VDR to exert its biological functions, either by activating VDR transcriptional activity to regulate gene expression associated with inflammation and fibrosis or by inducing intracellular signal transduction through VDR-mediated activation of Ca2+ channels. VDR activity has protective and detrimental effects on hepatic steatosis, a characteristic feature of NAFLD. Vitamin D-VDR signaling may control the progression of NAFLD by regulating immune responses, lipotoxicity, and fibrogenesis. Elucidation of the genetic and molecular background of VDR in the pathophysiology of NAFLD will provide new therapeutic targets for this disease through the development of VDR agonists, which already showed promising results in vivo.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1016/j.jsbmb.2022.106084
发表时间：
2022-05
期刊：
The Journal of steroid biochemistry and molecular biology
影响因子：
--
作者：
Arora J;Wang J;Weaver V;Zhang Y;Cantorna MT
通讯作者：
Cantorna MT
影响因子：
3.8
作者：
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通讯作者：
Aguilar-Salinas, Carlos Alberto
影响因子：
7.6
作者：
Angulo, P.
通讯作者：
Angulo, P.
影响因子：
25.7
作者：
Bozic, Milica;Guzman, Carla;Jover, Ramiro
通讯作者：
Jover, Ramiro