A prospective randomized controlled study on scheduled PDE5i and vacuum erectile devices in the treatment of erectile dysfunction after nerve sparing prostatectomy.
A prospective randomized controlled study on scheduled PDE5i and vacuum erectile devices in the treatment of erectile dysfunction after nerve sparing prostatectomy.
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预定 PDE5i 和真空勃起装置治疗保留神经前列腺切除术后勃起功能障碍的前瞻性随机对照研究
DOI：
10.4103/aja202189
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发表时间：
2022-09
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
海绵体神经损伤是勃起功能障碍(ED)的重要原因。尽管保护性神经技术在保留神经的前列腺癌根治术(NSRP)中得到了广泛应用，但术后ED的发生率仍然很高。本研究的目的是评价程序磷酸二酯酶5抑制剂(PDE5I)、真空勃起装置(VED)治疗NSRP后非勃起状态(PLNES)患者的勃起功能(EF)和阴茎长度。将100例EF正常的局限性前列腺癌患者随机分为PDE5i组、VED治疗组、联合治疗组和对照组，不加任何干预。分别于治疗6个月和12个月后进行国际勃起功能指数(IIEF-5)评分和PLNES评分。在治疗12个月后评估性行为特征(SEP-问题2和SEP-问题3)。100名随机患者中有91人完成了这项研究。我们发现，每天服用5 mg他达拉非(OAD)联合VED可以帮助NSRP患者在6个月和12个月后改善IIEF-5评分。VED单独或联合他达拉非OAD可帮助患者维持PLNES。VED联合他达拉非OAD可提高12个月后的穿刺率(SEP-问题2)。两组在12个月后恢复到目标EF方面没有显著差异。在干预12个月后，这些变量与恢复到目标EF(IIEF≥17)之间以及与患者阴茎有效缩短(缩短≥1 cm)之间没有明显的相关性。
Cavernous nerve injury is an important cause of erectile dysfunction (ED). Although protective nerve technology has been widely used in nerve-sparing radical prostatectomy (nsRP), the incidence of ED is still very high after surgery. The purpose of our study was to evaluate erectile function (EF) and penile length in the non-erectile state (PLNES) following scheduled phosphodiesterase 5 inhibitor (PDE5i), vacuum erectile device (VED) treatment, and combination therapy after nsRP. One hundred patients with localized prostate cancer and normal EF were randomized to scheduled PDE5i group, VED treatment group, a combined treatment group, and the control group without any intervention. The International Index of Erectile Function-5 (IIEF-5) scores and PLNES were evaluated after 6 months and 12 months of treatment. Sexual Encounter Profile (SEP-Question 2 and SEP-Question 3) were evaluated after 12 months of treatment. Ninety-one of the 100 randomized patients completed the study. We found that the 5 mg tadalafil once a day (OaD) combined with VED can help improve IIEF-5 scores in nsRP patients after both 6 months and 12 months. VED alone or combined with tadalafil OaD can help patients maintain PLNES. VED combined with tadalafil OaD can improve the rate of successful penetration (SEP-Question 2) after 12 months. There were no significant differences in the return to target EF after 12 months among the groups. No significant correlation was noted between the variables and return to target EF (IIEF ≥ 17), and between the variables and effective shortening of the patient's penis (shortening ≥ 1 cm) after 12 months of intervention.
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影响因子：
23.4
作者：
Capogrosso P;Vertosick EA;Benfante NE;Eastham JA;Scardino PJ;Vickers AJ;Mulhall JP
通讯作者：
Mulhall JP
影响因子：
3.6
作者：
Tian, Daxue;Wang, Xiao-yan;Zhang, Yong
通讯作者：
Zhang, Yong
影响因子：
3.5
作者：
Burnett, Arthur L.;Goldstein, Irwin;Xin, Zhong C.
通讯作者：
Xin, Zhong C.
影响因子：
4.5
作者：
Kim, D. J.;Hawksworth, D. J.;Dean, R. C.
通讯作者：
Dean, R. C.
机器人前列腺切除术后患者报告的生活质量恢复曲线在体重指数类别之间相似。
影响因子：
2.3
作者：
Garg T;Young AJ;Kost KA;Park AM;Danella JF;Kirchner HL
通讯作者：
Kirchner HL