Effects of urban living environments on mental health in adults.
Effects of urban living environments on mental health in adults.
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DOI：
10.1038/s41591-023-02365-w
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发表时间：
2023-06
期刊：
影响因子：
82.9
通讯作者：
Schumann, Gunter
中科院分区：
文献类型：
--
作者：
Xu, Jiayuan;Liu, Nana;Polemiti, Elli;Garcia-Mondragon, Liliana;Tang, Jie;Liu, Xiaoxuan;Lett, Tristram;Yu, Le;Noethen, Markus M.;Feng, Jianfeng;Yu, Chunshui;Marquand, Andre;Schumann, Gunter
城市生活的个体暴露在许多环境因素中，这些因素可能结合并相互作用影响心理健康。虽然对城市环境的各个因素进行了孤立的调查，但没有试图建立模型，说明现实生活中复杂的城市生活与大脑和精神健康之间的关系，以及这种关系如何受到遗传因素的调节。使用来自UK Biobank的156075名参与者的数据，我们进行了稀疏典型相关分析，以调查城市环境与精神症状之间的关系。我们发现社会剥夺、空气污染、街道网络和城市土地利用密度等环境特征与情感症状组呈正相关（r = 0.22, Pperm < 0.001），由与奖励加工一致的脑容量差异介导，并由富含应激反应的基因（包括CRHR1）调节，解释了2.01%的脑容量差异方差。保护因素如绿化和目的地可达性与焦虑症状组呈负相关（r = 0.10, Pperm < 0.001），由情绪调节所需的大脑区域介导，并由EXD3调节，解释1.65%的方差。第三个城市环境特征与情绪不稳定症状组相关（r = 0.03, Pperm < 0.001）。我们的研究结果表明，不同的城市生活环境可能通过不同的神经生物学途径影响特定的精神症状组。来自英国生物银行的数据分析显示，不同的城市生活环境与情感、焦虑和情绪不稳定症状组有关，并由不同的神经和遗传途径介导。
Urban-living individuals are exposed to many environmental factors that may combine and interact to influence mental health. While individual factors of an urban environment have been investigated in isolation, no attempt has been made to model how complex, real-life exposure to living in the city relates to brain and mental health, and how this is moderated by genetic factors. Using the data of 156,075 participants from the UK Biobank, we carried out sparse canonical correlation analyses to investigate the relationships between urban environments and psychiatric symptoms. We found an environmental profile of social deprivation, air pollution, street network and urban land-use density that was positively correlated with an affective symptom group (r = 0.22, Pperm < 0.001), mediated by brain volume differences consistent with reward processing, and moderated by genes enriched for stress response, including CRHR1, explaining 2.01% of the variance in brain volume differences. Protective factors such as greenness and generous destination accessibility were negatively correlated with an anxiety symptom group (r = 0.10, Pperm < 0.001), mediated by brain regions necessary for emotion regulation and moderated by EXD3, explaining 1.65% of the variance. The third urban environmental profile was correlated with an emotional instability symptom group (r = 0.03, Pperm < 0.001). Our findings suggest that different environmental profiles of urban living may influence specific psychiatric symptom groups through distinct neurobiological pathways. Analyses of data from the UK Biobank reveal different urban living environments that are associated with affective, anxiety and emotional instability symptom groups and mediated by distinct neurological and genetic pathways in adults.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
16.6
作者：
Huang J;Howie B;McCarthy S;Memari Y;Walter K;Min JL;Danecek P;Malerba G;Trabetti E;Zheng HF;UK10K Consortium;Gambaro G;Richards JB;Durbin R;Timpson NJ;Marchini J;Soranzo N
通讯作者：
Soranzo N
影响因子：
14.9
作者：
Chen J;Bardes EE;Aronow BJ;Jegga AG
通讯作者：
Jegga AG