microRNA profiles and functions in mosquitoes.
microRNA profiles and functions in mosquitoes.
复制标题
DOI：
10.1371/journal.pntd.0006463
复制
发表时间：
2018-05
影响因子：
3.8
通讯作者：
Hu W
中科院分区：
文献类型：
--
作者：
Feng X;Zhou S;Wang J;Hu W
蚊子是许多致残性疾病的传播媒介，包括疟疾、西尼罗热、登革热和其他被忽视的热带病。microRNAs （miRNAs）可以与多个靶基因相互作用，从而在蚊子体内引发生物学功能。然而，迄今为止，单个mirna及其潜在靶点的表征和功能尚未完全确定。我们根据PRISMA指南对已发表的文献进行了系统的综述。我们总结了关于蚊子mirna的信息，以便更好地了解它们的代谢、发育和对微生物的反应。根据研究结果，我们发现mirna以物种、性别、阶段和组织/器官特异性的方式失调。在发育、代谢、宿主-病原体相互作用和杀虫剂抗性中观察到异常的miRNA表达。值得注意的是，许多mirna在病原体感染时下调。实验研究将miRNA靶点的鉴定从蚊子mrna的3′非翻译区（UTRs）扩展到病毒mrna的5′非翻译区。此外，我们还讨论了蚊子miRNA研究的当前趋势，并对未来的研究提出了建议。数以百万计的人类感染是由蚊子传播的疾病引起的，因此了解决定传播效率变异和昆虫易感性的分子和遗传机制可能有助于制定新的媒介控制策略。最近，在脊椎动物、无脊椎动物和病毒中，microRNAs （miRNAs）作为基因表达的转录后调控因子被研究。由于病媒和寄生虫之间的相互作用是疟疾传播动力学的关键，鉴定参与蚊子发育周期和蚊子与病原体之间允许生存、增殖和疾病传播的相互作用的mirna可能有助于疾病控制。本文综述了蚊虫mirna在各种生理病理过程中的表达和功能，并对未来的研究进行了展望。
Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms. Depending on the study, we found that miRNAs were dysregulated in a species-, sex-, stage-, and tissue/organ-specific manner. Aberrant miRNA expressions were observed in development, metabolism, host-pathogen interactions, and insecticide resistance. Of note, many miRNAs were down-regulated upon pathogen infection. The experimental studies have expanded the identification of miRNA target from the 3′ untranslated regions (UTRs) of mRNAs of mosquitoes to the 5′ UTRs of mRNAs of the virus. In addition, we discuss current trends in mosquito miRNA research and offer suggestions for future studies. Millions of human infections are caused by mosquito-borne diseases, so understanding the molecular and genetic mechanisms that determine variability in transmission efficiency and insect susceptibility may assist with novel vector control strategies. Recently, microRNAs (miRNAs) have been studied as post-transcriptional regulators of gene expression in vertebrates, invertebrates, and viruses. Because interactions between vectors and parasites are the keys to malarial transmission dynamics, identifying miRNAs involved in the developmental cycles of the mosquito and interactions between the mosquito and pathogens that allow the survival, proliferation, and disease transmission may help with disease control. In this review, we summarize the research on mosquito miRNAs regarding their expression and function in various physiological and pathological processes, and explore future research in this area.
登录
查看更多内容
影响因子：
3.7
作者：
Gu J;Hu W;Wu J;Zheng P;Chen M;James AA;Chen X;Tu Z
通讯作者：
Tu Z
影响因子：
2.6
作者：
Campbell CL;Harrison T;Hess AM;Ebel GD
通讯作者：
Ebel GD
影响因子：
4.4
作者：
Biryukova, Inna;Ye, Tao;Levashina, Elena
通讯作者：
Levashina, Elena
影响因子：
14.9
作者：
Griffiths-Jones, S;Bateman, A;Eddy, SR
通讯作者：
Eddy, SR
影响因子：
2.9
作者：
Dennison, Nathan J.;BenMarzouk-Hidalgo, Omar J.;Dimopoulos, George
通讯作者：
Dimopoulos, George