Economic outcomes of patients receiving antiretroviral therapy for HIV/AIDS in South Africa are sustained through three years on treatment.
Economic outcomes of patients receiving antiretroviral therapy for HIV/AIDS in South Africa are sustained through three years on treatment.
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DOI：
10.1371/journal.pone.0012731
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发表时间：
2010-09-14
期刊：
影响因子：
3.7
通讯作者：
Sanne I
中科院分区：
文献类型：
--
作者：
Rosen S;Larson B;Brennan A;Long L;Fox M;Mongwenyana C;Ketlhapile M;Sanne I
虽然艾滋病毒/艾滋病的抗逆转录病毒疗法(ART)的医疗效果得到了很好的描述，但人们对ART如何影响患者的经济活动和生活质量知之甚少，特别是在ART治疗的第一年之后。我们评估了南非成人抗逆转录病毒治疗患者在ART启动后整整三年的症状患病率、一般健康状况、进行正常活动的能力和就业状况。855名成年抗逆转录病毒治疗前患者和接受抗逆转录病毒治疗6个月的患者入选队列，在治疗开始后长达三年的常规门诊期间，使用为该研究设计的工具，平均每人采访4.4次。前一周疼痛的概率从ART开始前的74%下降到ART三年后的32%，疲劳从66%下降到12%，恶心从28%下降到4%，皮肤问题从55%下降到10%。昨天身体不适的概率从46%下降到23%。在开始抗逆转录病毒治疗之前，39%的受试者报告在前一周的某个时间无法进行正常活动；三年后，这一比例下降到10%。就业率从27%上升到42%。所有结果的改善持续了3年，有些结果在第二年和第三年有所增加。成人抗逆转录病毒治疗患者的症状患病率、一般健康状况、正常活动能力和就业状况的改善幅度很大，并在治疗的前三年持续存在。这些结果表明，大规模治疗提供所预期的一些积极的经济和社会外部性，如劳动力参与率和生产率的提高以及患者继续正常生活的能力，确实可能正在积累。
Although the medical outcomes of antiretroviral therapy (ART) for HIV/AIDS are well described, less is known about how ART affects patients' economic activities and quality of life, especially after the first year on ART. We assessed symptom prevalence, general health, ability to perform normal activities, and employment status among adult antiretroviral therapy patients in South Africa over three full years following ART initiation. A cohort of 855 adult pre-ART patients and patients on ART for <6 months was enrolled and interviewed an average of 4.4 times each during routine clinic visits for up to three years after treatment initiation using an instrument designed for the study. The probability of pain in the previous week fell from 74% before ART initiation to 32% after three years on ART, fatigue from 66% to 12%, nausea from 28% to 4%, and skin problems from 55% to 10%. The probability of not feeling well physically yesterday fell from 46% to 23%. Before starting ART, 39% of subjects reported not being able to perform their normal activities sometime during the previous week; after three years, this proportion fell to 10%. Employment rose from 27% to 42% of the cohort. Improvement in all outcomes was sustained over 3 years and for some outcomes increased in the second and third year. Improvements in adult ART patients' symptom prevalence, general health, ability to perform normal activities, and employment status were large and were sustained through the first three years on treatment. These results suggest that some of the positive economic and social externalities anticipated as a result of large-scale treatment provision, such as increases in workforce participation and productivity and the ability of patients to carry on normal lives, may indeed be accruing.
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影响因子：
11.8
作者：
Ivers, LC;Kendrick, D;Doucette, K
通讯作者：
Doucette, K
DOI：
10.1177/1545109708320684
发表时间：
2008-07-01
期刊：
Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
影响因子：
--
作者：
Rosen, Sydney;Ketlhapile, Mpefe;DeSilva, Mary Bachman
通讯作者：
DeSilva, Mary Bachman
DOI：
10.1080/09540120903038366
发表时间：
2010-01-01
影响因子：
1.7
作者：
Fox, Matthew P.;Mccoy, Kelly;Simon, Jonathon L.
通讯作者：
Simon, Jonathon L.
影响因子：
3.8
作者：
Rosen, Sydney;Kethapile, Mpefe;DeSilva, Mary Bachman
通讯作者：
DeSilva, Mary Bachman
影响因子：
3.8
作者：
Etard, JF;Ndiaye, I;Delaporte, E
通讯作者：
Delaporte, E