Trajectories of Mother-Infant Communication: An Experiential Measure of the Impacts of Early Life Adversity.
Trajectories of Mother-Infant Communication: An Experiential Measure of the Impacts of Early Life Adversity.
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DOI：
10.3389/fnhum.2021.632702
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发表时间：
2021
影响因子：
2.9
通讯作者：
Brenhouse H
中科院分区：
文献类型：
--
作者：
Granata L;Valentine A;Hirsch JL;Honeycutt J;Brenhouse H
照顾稳定的早期生活环境支持神经行为的发展，而不稳定和忽视构成不利的环境，可以改变成熟的过程。对人类的研究表明，不同类型的早期生活逆境（ELA）可能对照顾者关系以及后来的认知和社会发展产生不同的影响;然而，确定机制基础需要具有翻译有效性的动物模型。两种常见的啮齿动物模型，母亲分离（MS）和有限的床上用品（LB），影响母婴关系在一个关键的窗口的发展。我们假设，这些范例可能会影响发展的沟通策略的一部分，小狗。超声波发声（USVs）是一种照顾引发机制和行为学相关的反应，在大鼠幼崽的压力。USV发射率和声学参数在整个早期发育过程中发生变化，这为定义USV的发育里程碑提供了机会，这些里程碑如果中断，将反映神经行为畸变。本研究通过量化幼鼠USV、母性行为以及两者之间的关系，研究了MS或LB对母鼠-幼鼠关系的影响。首先，我们使用广义加性模型方法来建立USV声学特性的典型发展轨迹并确定MS或LB饲养的变化窗口。此外，我们量化产妇的行为和产妇护理序列的可预测性，使用熵率计算。MS和LB各自以性别特异性方式改变USV声学参数和呼叫类型的发展轨迹。MS更经常影响男性USV，而LB影响女性USV。MS母鼠花更多的时间被动护理，LB母鼠花更多的时间在巢上。产妇护理的可预测性与USV排放率仅在女性。两者合计，研究结果表明，性别和模型特定的影响，养育环境的一个新的发展轨迹，涉及母婴关系，促进翻译的动物ELA范式，以评估以后的生活后果。
Caretaking stability in the early life environment supports neurobehavioral development, while instability and neglect constitute adverse environments that can alter maturational processes. Research in humans suggests that different types of early life adversity (ELA) can have differential effects on caretaker relationships and later cognitive and social development; however, identifying mechanistic underpinnings will require animal models with translational validity. Two common rodent models, maternal separation (MS) and limited bedding (LB), influence the mother-infant relationship during a critical window of development. We hypothesized that these paradigms may affect the development of communication strategies on the part of the pup. Ultrasonic vocalizations (USVs) are a care-eliciting mechanism and ethologically relevant response to stressors in the rat pup. USV emission rates and acoustic parameters change throughout early development, presenting the opportunity to define developmental milestones in USVs that would reflect neurobehavioral aberrations if disrupted. This study investigated the effects of MS or LB on the dam-pup relationship by quantifying pup USVs, maternal behavior, and the relationship between the two. First, we used a generalized additive model approach to establish typical developmental trajectories of USV acoustic properties and determine windows of change in MS or LB rearing. Additionally, we quantified maternal behaviors and the predictability of maternal care sequences using an entropy rate calculation. MS and LB each shifted the developmental trajectories of USV acoustic parameters and call types in a sex-specific manner. MS more often impacted male USVs, while LB impacted female USVs. MS dams spent more time passive nursing, and LB dams spent more time on the nest. The predictability of maternal care was associated with the rate of USV emissions exclusively in females. Taken together, findings demonstrate sex- and model-specific effects of rearing environments on a novel developmental trajectory involving the mother-infant relationship, facilitating the translation of animal ELA paradigms to assess later-life consequences.
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影响因子：
4
作者：
Beebe B;Myers MM;Lee SH;Lange A;Ewing J;Rubinchik N;Andrews H;Austin J;Hane A;Margolis AE;Hofer M;Ludwig RJ;Welch MG
通讯作者：
Welch MG
影响因子：
2.6
作者：
Brudzynski, SM
通讯作者：
Brudzynski, SM
影响因子：
2.6
作者：
Ehret, G
通讯作者：
Ehret, G
影响因子：
3.7
作者：
Aisa, Barbara;Tordera, Rosa;Ramirez, Maria J.
通讯作者：
Ramirez, Maria J.
早期压力作为酒精和药物依赖性的预测因素。
影响因子：
3.4
作者：
Enoch, Mary-Anne
通讯作者：
Enoch, Mary-Anne