Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.
Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.
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DOI：
10.1016/j.stem.2008.07.004
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发表时间：
2008-09-11
期刊：
影响因子：
23.9
通讯作者：
Alvarez-Buylla A
中科院分区：
文献类型：
--
作者：
Mirzadeh Z;Merkle FT;Soriano-Navarro M;Garcia-Verdugo JM;Alvarez-Buylla A
Neural stem cells (NSCs, B1 cells) are retained in the walls of the adult lateral ventricles, but unlike embryonic NSCs, are displaced from the ventricular zone (VZ) into the subventricular zone (SVZ) by ependymal cells. Apical and basal compartments, which in embryonic NSCs play essential roles in self-renewal and differentiation, are not evident in adult NSCs. Here we show that adult SVZ B1 cells extend a minute apical ending to directly contact the ventricle and a long basal process ending on blood vessels. A closer look at the ventricular surface reveals a striking pinwheel organization specific to regions of adult neurogenesis. The pinwheel’s core contains the apical endings of B1 cells and in its periphery two types of ependymal cells: multiciliated (E1) and a novel type (E2) characterized by only 2 cilia and extraordinarily complex basal bodies. These results reveal that adult NSCs retain fundamental epithelial properties, including apical and basal compartmentalization, significantly reshaping our understanding of this adult neurogenic niche.
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DOI：
10.1073/pnas.0710000105
发表时间：
2008-01-22
影响因子：
11.1
作者：
Coskun, Volkan;Wu, Hao;Sun, Yi E.
通讯作者：
Sun, Yi E.
影响因子：
30.8
作者：
Gerdes, Jantje M.;Liu, Yangfan;Katsanis, Nicholas
通讯作者：
Katsanis, Nicholas
影响因子：
25
作者：
Denise, A;Garcia, R;Sofroniew, MV
通讯作者：
Sofroniew, MV
影响因子：
64.8
作者：
Corbit, KC;Aanstad, P;Reiter, JF
通讯作者：
Reiter, JF
影响因子：
2.5
作者：
Gomez-Roldan, Maria Del Carmen;Perez-Martin, Margarita;Fernandez-Llebrez, Pedro
通讯作者：
Fernandez-Llebrez, Pedro