Physical Limits on the Precision of Mitotic Spindle Positioning by Microtubule Pushing forces: Mechanics of mitotic spindle positioning.
Physical Limits on the Precision of Mitotic Spindle Positioning by Microtubule Pushing forces: Mechanics of mitotic spindle positioning.
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DOI：
10.1002/bies.201700122
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Garzon-Coral C
中科院分区：
文献类型：
--
作者：
Howard J;Garzon-Coral C
Tissues are shaped and patterned by mechanical and chemical processes. A key mechanical process is the positioning of the mitotic spindle, which determines the size and location of the daughter cells within the tissue. Recent force and fluctuation measurements indicate that pushing forces, mediated by the polymerization of astral microtubules against the cell cortex, maintain the mitotic spindle at the cell center in C. elegans embryos. The magnitude of the centering forces suggests that the physical limit on the accuracy and precision of this centering mechanism is determined by the number of pushing microtubules rather than by thermally driven fluctuations. In cells that divide asymmetrically, anti-centering, pulling forces generated by cortically located dyneins, in conjunction with microtubule depolymerization, oppose the pushing forces to drive spindle displacements away from the center. Thus, a balance of centering pushing forces and anti-centering pulling forces localize the mitotic spindles within dividing C. elegans cells. We discussmicrotubule-based mechanisms of the mitotic spindle positioning, a key mechanical process that shapes and patterns tissues. The magnitude of the centering forcesindicates that the physical limiton the accuracy and precision of centering isset by the number of contributing microtubules rather than by thermally driven fluctuations.
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