Beta-catenin is required for memory consolidation.
Beta-catenin is required for memory consolidation.
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β-连环蛋白是记忆巩固所必需的。
DOI：
10.1038/nn.2198
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发表时间：
2008-11
影响因子：
25
通讯作者：
Ressler, Kerry J.
中科院分区：
文献类型：
--
作者：
Maguschak, Kimberly A.;Ressler, Kerry J.
β-连环蛋白因其在发育中的作用而被确定，与神经元突触的调节和重塑有关。我们检测了β-catenin在成年小鼠大脑中的表达及其在杏仁核依赖性学习和记忆中的作用。我们发现在恐惧记忆巩固过程中β-连环蛋白mRNA和蛋白磷酸化发生改变。这种改变与β-连环蛋白与钙粘蛋白的关联变化相关。药理学上，锂介导的β-catenin的促进作用增强了这种巩固。遗传学上，β-catenin的作用通过杏仁核中固定的β-catenin的位点特异性缺失得到证实。基线运动、焦虑相关行为和条件恐惧的获得或表达均正常。然而，杏仁核特异性缺失阻止了新形成的恐惧学习转化为长期记忆的正常转移。因此，杏仁核内的β-连环蛋白可能需要正常的巩固，而不是获得恐惧记忆。这表明β-连环蛋白在成人长期记忆的突触重塑和稳定中起着普遍的作用。
Identified for its role in development, β-catenin has been implicated in neuronal synapse regulation and remodeling. We examined β-catenin expression in the adult mouse brain and its role in amygdala-dependent learning and memory. We found alterations in β-catenin mRNA and protein phosphorylation during fear memory consolidation. Such alterations correlated with a change in the association of β-catenin with cadherin. Pharmacologically, this consolidation was enhanced with lithium-mediated facilitation of β-catenin. Genetically, the role of β-catenin was confirmed with site-specific deletions of floxed β-catenin in the amygdala. Baseline locomotor, anxiety-related behaviors, and the acquisition or expression of conditioned fear were normal. However, amygdala-specific deletion prevented the normal transfer of newly formed fear learning into long-term memory. Thus, β-catenin within the amygdala may be required for the normal consolidation, but not acquisition, of fear memory. This suggests a general role for β-catenin in synaptic remodeling and stabilization underlying long-term memory in adults.
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影响因子：
56.9
作者：
Behrens, J;Jerchow, BA;Birchmeier, W
通讯作者：
Birchmeier, W
影响因子：
7.6
作者：
Gould, Todd D.;O'Donnell, Kelley C.;Manji, Husseini K.
通讯作者：
Manji, Husseini K.
影响因子：
16.2
作者：
Nägerl, UV;Eberhorn, N;Bonhoeffer, T
通讯作者：
Bonhoeffer, T
DOI：
10.1073/pnas.93.21.11382
发表时间：
1996-10-15
影响因子：
11.1
作者：
Naldini, L;Blomer, U;Verma, IM
通讯作者：
Verma, IM
影响因子：
56.9
作者：
Naldini, L;Blomer, U;Trono, D
通讯作者：
Trono, D