Cell cycle control of kinetochore assembly.

Cell cycle control of kinetochore assembly.
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DOI:
10.1080/19491034.2022.2115246
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发表时间:
2022-12
期刊:
Nucleus (Austin, Tex.)
影响因子:
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其他
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着丝粒是组装在染色体着丝粒上的大型蛋白质结构。这种复杂的机制将染色体与有丝分裂纺锤体连接起来,对于细胞分裂过程中染色体的准确分离至关重要。着丝粒由两个子模块组成:内着丝粒和外着丝粒。内着丝粒组装在着丝粒染色质上,并在整个细胞周期中与着丝粒一起持续存在。外着丝粒将微管附着到内着丝粒上,并且仅在有丝分裂期间组装。该综述重点关注我们对有丝分裂期间外着丝粒正确组装机制的理解的最新进展,并强调了未来研究的开放性问题。
The kinetochore is a large proteinaceous structure assembled on the centromeres of chromosomes. The complex machinery links chromosomes to the mitotic spindle and is essential for accurate chromosome segregation during cell division. The kinetochore is composed of two submodules: the inner and outer kinetochore. The inner kinetochore is assembled on centromeric chromatin and persists with centromeres throughout the cell cycle. The outer kinetochore attaches microtubules to the inner kinetochore, and assembles only during mitosis. The review focuses on recent advances in our understanding of the mechanisms governing the proper assembly of the outer kinetochore during mitosis and highlights open questions for future investigation.
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