A VEL3 histone deacetylase complex establishes a maternal epigenetic state controlling progeny seed dormancy.

A VEL3 histone deacetylase complex establishes a maternal epigenetic state controlling progeny seed dormancy.
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一个VEL3组蛋白去乙酰化酶复合体建立起一种母本表观遗传状态,该状态控制着子代种子的休眠。

DOI:
10.1038/s41467-023-37805-1
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发表时间:
2023-04-19
影响因子:
16.6
通讯作者:
Penfield, Steven
Penfield, Steven
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Chen, Xiaochao;MacGregor, Dana R. R.;Stefanato, Francesca L. L.;Zhang, Naichao;Barros-Galvao, Thiago;Penfield, Steven

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母株在控制后代休眠和扩散特性方面起着重要作用。在拟南芥中,种子休眠是由胚乳和种皮的胚周围组织施加的。在这里,我们表明,VERNALIZATION 5/VIN 3-LIKE 3(VEL 3)通过在中央细胞中建立一种表观遗传状态来维持对后代种子休眠的母系控制,该表观遗传状态引发了随后在种子成熟过程中建立的初级种子休眠的深度。VEL 3与MSI 1共定位于核仁中,并与组蛋白脱乙酰酶复合物结合。此外,VEL 3优先与近着丝粒染色质结合,并且是在中央细胞中建立的去乙酰化和H3 K27 me 3沉积所必需的。由母体VEL 3建立的表观遗传状态保留在成熟种子中,并通过抑制程序性细胞死亡相关基因ORE 1部分控制种子休眠。我们的数据证明了一种机制,通过这种机制,母体控制后代种子生理持续脱落后,保持亲本控制种子行为。母株在决定子代扩散特性方面起着重要作用。在这里,作者表明,VEL 3组蛋白脱乙酰酶复合物建立了控制后代种子休眠的母体表观遗传状态。
Mother plants play an important role in the control of dormancy and dispersal characters of their progeny. In Arabidopsis seed dormancy is imposed by the embryo-surrounding tissues of the endosperm and seed coat. Here we show that VERNALIZATION5/VIN3-LIKE 3 (VEL3) maintains maternal control over progeny seed dormancy by establishing an epigenetic state in the central cell that primes the depth of primary seed dormancy later established during seed maturation. VEL3 colocalises with MSI1 in the nucleolus and associates with a histone deacetylase complex. Furthermore, VEL3 preferentially associates with pericentromeric chromatin and is required for deacetylation and H3K27me3 deposition established in the central cell. The epigenetic state established by maternal VEL3 is retained in mature seeds, and controls seed dormancy in part through repression of programmed cell death-associated gene ORE1. Our data demonstrates a mechanism by which maternal control of progeny seed physiology persists post-shedding, maintaining parental control of seed behaviour. Mother plants play an important role in determining the dispersal characteristics of their progeny. Here the authors show that a VEL3 histone deacetylase complex establishes a maternal epigenetic state controlling progeny seed dormancy.
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