Neuronal On- and Off-type heterogeneities improve population coding of envelope signals in the presence of stimulus-induced noise
Neuronal On- and Off-type heterogeneities improve population coding of envelope signals in the presence of stimulus-induced noise
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神经元开型和关型异质性改善了存在刺激引起的噪声时包络信号的群体编码
DOI：
10.1038/s41598-020-67258-1
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发表时间：
2020
影响因子：
4.6
通讯作者：
Chacron MJ
中科院分区：
文献类型：
--
作者：
Hofmann V ;Chacron MJ
了解神经元群体活动引起感知和行为的机制仍然是系统神经科学的中心问题。由于自然刺激往往具有复杂的结构，这种理解变得复杂起来。在这里，我们研究了感觉神经元群体中的异质性如何影响噪声刺激波形(即噪声)及其行为相关包络信号(即信号)的编码。我们发现On和Off类型的神经元在对噪声的反应上比在对信号的反应上表现出更多的异质性。这些异质性的差异在量化神经元对之间的反应相似性时产生了重要的后果。事实上，On-type和Off-type神经元表现出的更大的反应异质性使得它们对噪声的成对反应平均比考虑On-type或Off类型神经元对噪声的反应更独立。这种相对独立性允许在混合类型(即，开启和关闭类型)中汇集神经活动时比对于相同类型(即，仅开启类型或仅关闭类型)更好地平均噪声响应，从而导致关于信号的更大信息传输。因此，我们的结果揭示了On和Off类型神经元的组合活动在种群水平上改善包络刺激的信息传递的功能。我们的结果可能会推广，因为跨模式的自然刺激的特征是其包络独立变化的刺激波形，以及因为跨系统和跨物种观察到开关类型的神经元。
Understanding the mechanisms by which neuronal population activity gives rise to perception and behavior remains a central question in systems neuroscience. Such understanding is complicated by the fact that natural stimuli often have complex structure. Here we investigated how heterogeneities within a sensory neuron population influence the coding of a noisy stimulus waveform (i.e., the noise) and its behaviorally relevant envelope signal (i.e., the signal). We found that On- and Off-type neurons displayed more heterogeneities in their responses to the noise than in their responses to the signal. These differences in heterogeneities had important consequences when quantifying response similarity between pairs of neurons. Indeed, the larger response heterogeneity displayed by On- and Off-type neurons made their pairwise responses to the noise on average more independent than when instead considering pairs of On-type or Off-type neurons. Such relative independence allowed for better averaging out of the noise response when pooling neural activities in a mixed-type (i.e., On- and Off-type) than for same-type (i.e., only On-type or only Off-type), thereby leading to greater information transmission about the signal. Our results thus reveal a function for the combined activities of On- and Off-type neurons towards improving information transmission of envelope stimuli at the population level. Our results will likely generalize because natural stimuli across modalities are characterized by a stimulus waveform whose envelope varies independently as well as because On- and Off-type neurons are observed across systems and species.
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DOI：
10.1098/rspb.1981.0033
发表时间：
1981
期刊：
Proceedings of the Royal Society of London. Series B. Biological Sciences
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DOI：
--
发表时间：
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期刊：
The Journal of comparative neurology
影响因子：
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