Developmental and genetic origins of murine long bone length variation.
Developmental and genetic origins of murine long bone length variation.
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小鼠长骨长度变异的发育和遗传起源。
DOI：
10.1002/jez.b.21388
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Cheverud,JamesM
中科院分区：
文献类型：
--
作者：
Sanger,ThomasJ;Norgard,ElizabethA;Pletscher,LSusan;Bevilacqua,Michael;Brooks,VictoriaR;Sandell,LindaJ;Cheverud,JamesM
如果我们希望了解发育是否影响形态进化的速度或方向，我们必须首先了解种内形态变异的发育基础。然而，成体形态的数量变化是从胚胎发育到幼年生长到成熟的分子和细胞过程的产物。阿奇利-霍尔模型提供了一个有用的框架，用于将复杂的形态解剖成其组成部分，作为确定哪些发育过程有助于成人形式变化的一种方式。我们已经研究了出生后异速生长的差异和年龄特异性性状之间的遗传相关模式的重组近交系小鼠产生的LG/J和SM/J的互交。长骨长度与身体大小密切相关，但成年形态的变化更密切地联系在3和5周龄之间的生长速度的差异。这些分析表明，在早期发展过程中产生的变化是由后来在生活中产生的变化覆盖。为了更精确地确定产生这种变化的细胞过程，我们随后检查了在亲本菌株中最大伸长率差异时长骨生长板的细胞动力学。我们的分析表明，长骨长度的变化是LG/J染色剂更快的伸长速率的结果。这些生长速率差异的发育基础涉及生长板中细胞分裂和软骨细胞肥大的速率。Zool.（Mol. Dev. Evol.）316：146-161，2011.© 2010 Wiley利斯公司
If we wish to understand whether development influences the rate or direction of morphological evolution, we must first understand the developmental bases of morphological variationwithinspecies. However, quantitative variation in adult morphology is the product of molecular and cellular processes unfolding from embryonic development through juvenile growth to maturity. The Atchley–Hall model provides a useful framework for dissecting complex morphologies into their component parts as a way of determining which developmental processes contribute to variation in adult form. We have examined differences in postnatal allometry and the patterns of genetic correlation between age‐specific traits for ten recombinant inbred strains of mice generated from an intercross of LG/J and SM/J. Long bone length is closely tied to body size, but variation in adult morphology is more closely tied to differences in growth rate between 3 and 5 weeks of age. These analyses show that variation generated during early development is overridden by variation generated later in life. To more precisely determine the cellular processes generating this variation we then examined the cellular dynamics of long bone growth plates at the time of maximum elongation rate differences in the parent strains. Our analyses revealed that variation in long bone length is the result of faster elongation rates of the LG/J stain. The developmental bases for these differences in growth rate involve the rate of cell division and chondrocyte hypertrophy in the growth plate.J. Exp. Zool. (Mol. Dev. Evol.) 316:146–161, 2011. © 2010 Wiley‐Liss, Inc.
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