Magnetic resonance imaging-guided and targeted theranostics of colorectal cancer

Magnetic resonance imaging-guided and targeted theranostics of colorectal cancer
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磁共振成像引导的结直肠癌靶向治疗诊断

DOI:
10.20892/j.issn.2095-3941.2020.0072
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发表时间:
2020-05
影响因子:
5.5
通讯作者:
An Feifei
An Feifei
中科院分区:
医学2区
文献类型:
--
作者:
Li Yanan;Xin Jingqi;Sun Yongbing;Han Tao;Zhang Hui;An Feifei

文献摘要

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结直肠癌(CRC)是世界范围内最常见的胃肠道癌症,并且与高发病率和死亡率相关。纳米给药系统的发展为结直肠癌的治疗提供了新的方向。在这些系统中,基于磁性纳米颗粒(MNP)的多功能平台为磁共振成像(MRI)相关的癌症治疗诊断提供了一种新的策略。本文首先对结直肠癌的发生机制和治疗现状进行了综述。然后,系统地分析了MNP的各种制备方法和功能化方法,以及MRI介入的治疗诊断策略。MRI介导的多模式诊断和图像引导的靶向治疗在CRC管理中的最新进展是主要焦点。最后,在临床实践中促进MRI诱导的CRC精确治疗诊断的主要挑战进行了讨论。
Colorectal cancer (CRC) is the most common gastrointestinal tract cancer worldwide and is associated with high morbidity and mortality. The development of nanosized drug delivery systems has provided a new direction in CRC treatment. Among these systems, magnetic nanoparticle (MNP)-based multifunctional platforms provide a novel strategy for magnetic resonance imaging (MRI)-related cancer theranostics. At the beginning of this original review, the carcinogenesis and treatment status of CRC are summarized. Then, diversified preparation and functionalization methods of MNPs are systematically analyzed, followed by MRIinvolved theranostic strategies. The latest progress in MRI-mediated multimode diagnosis and image-guided targeted therapy in CRC management is the main focus. Finally, the major challenges in promoting MRI-induced precise theranostics of CRC in clinical practice are discussed.
DOI: 10.1007/978-1-4939-9027-6_2
发表时间: 2019
影响因子: --
作者:
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通讯作者: T. Witney;D. Lewis
DOI: 10.1007/978-3-642-51881-2_97
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