Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells

Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells
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小鼠细胞骨架γ-肌动蛋白 cDNA 克隆的分离以及小鼠细胞中细胞骨架肌动蛋白 mRNA 的差异表达

DOI:
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发表时间:
1988
影响因子:
5.3
通讯作者:
K. Takenaga
K. Takenaga
中科院分区:
生物学2区
文献类型:
--
作者:
K. Tokunaga;Kyoko Takeda;Kiyofumi;Kamiyama;H. Kageyama;K. Takenaga

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我们描述了小鼠细胞骨架γ-肌动蛋白基因克隆的结构,并表明非翻译区与人的伽马-肌动蛋白基因有很强的保守性。此外,我们还发现,在不同的小鼠组织和细胞类型中,β-和γ-肌动蛋白mRNAs的表达水平是不同的,但在细胞生长状态下是协调增加的。这些结果表明,细胞骨架肌动蛋白基因存在多种调控机制,这与哺乳动物细胞中β-和γ-肌动蛋白可能具有功能多样性的观点是一致的。
We described the structures of mouse cytoskeletal gamma-actin cDNA clones and showed that there is strong conservation of the untranslated regions with human gamma-actin cDNA. In addition, we found that the expression levels of beta- and gamma-actin mRNAs are differentially controlled in various mouse tissues and cell types but are coordinately increased in the cellular growing state. These results suggest that there are multiple regulatory mechanisms of cytoskeletal actin genes and are consistent with the argument that beta- and gamma-actins might have functional diversity in mammalian cells.
致瘤性人成纤维细胞中原肌球蛋白异构体的转换。
DOI: 10.1128/mcb.6.7.2721-2726.1986
发表时间: 1986
影响因子: 5.3
作者:
Leavitt,J;Latter,G;Lutomski,L;Goldstein,D;Burbeck,S
通讯作者: Burbeck,S
DOI: 10.1073/pnas.81.23.7476
发表时间: 1984-01-01
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子: --
作者:
ELDER, PK;SCHMIDT, LJ;GETZ, MJ
通讯作者: GETZ, MJ