Involvement of IL-18 in the expansion of unique hepatic T cells with unconventional cytokine profiles during Schistosoma mansoni infection.
Involvement of IL-18 in the expansion of unique hepatic T cells with unconventional cytokine profiles during Schistosoma mansoni infection.
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DOI：
10.1371/journal.pone.0096042
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hamano S
中科院分区：
文献类型：
--
作者：
Adachi K;Nakamura R;Osada Y;Senba M;Tamada K;Hamano S
病毒体感染引起宿主肝脏严重的纤维化肉芽肿反应。曼氏血吸虫感染诱导Th 1或Th 2细胞因子反应系统性的戏剧性波动; Th 1反应在早期阶段被挑起，而Th 2反应在产卵开始后成为主导。在肝脏中，存在不同于常规免疫活性器官或组织的各种独特的免疫细胞，从而产生独特的免疫环境。最近，我们证明了S。在Th 1-和Th 2-阶段之间的时期（我们称之为过渡阶段），曼氏菌感染诱导独特的CD 4 + T细胞群在小鼠肝脏中表现出非常规的细胞因子谱。它们同时产生IFN-γ和IL-4或IFN-γ和IL-13。此外，还诱导分泌三重细胞因子IFN-γ、IL-13和IL-4的T细胞。我们将这些细胞称为产生多种细胞因子的肝脏T细胞（MCPHT细胞）。在过渡期，当MCPHT细胞增加时，肝脏和血清中IL-18分泌上调。In S.在mansoni感染的IL-18缺陷小鼠中，MCPHT细胞的扩增减少。因此，我们的数据表明，IL-18在S. mansoni感染在MCPHT细胞的扩增中起作用。
Infection with schistosomes invokes severe fibrotic granulomatous responses in the liver of the host. Schistosoma mansoni infection induces dramatic fluctuations in Th1 or Th2 cytokine responses systemically; Th1 reactions are provoked in the early phase, whilst Th2 responses become dominant after oviposition begins. In the liver, various unique immune cells distinct from those of conventional immune competent organs or tissues exist, resulting in a unique immunological environment. Recently, we demonstrated that S. mansoni infection induces unique CD4+ T cell populations exhibiting unconventional cytokine profiles in the liver of mice during the period between Th1- and Th2-phases, which we term the transition phase. They produce both IFN-γ and IL-4 or both IFN-γ and IL-13 simultaneously. Moreover, T cells secreting triple cytokines IFN-γ, IL-13 and IL-4 were also induced. We term these cells Multiple Cytokine Producing Hepatic T cells (MCPHT cells). During the transition phase, when MCPHT cells increase, IL-18 secretion was up-regulated in the liver and sera. In S. mansoni-infected IL-18-deficient mice, expansion of MCPHT cells was curtailed. Thus our data suggest that IL-18 produced during S. mansoni infection play a role in the expansion of MCPHT cells.
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