Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection.
Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection.
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DOI：
10.1371/journal.pone.0082698
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hamano S
中科院分区：
文献类型：
--
作者：
Adachi K;Osada Y;Nakamura R;Tamada K;Hamano S
在血吸虫感染期间，宿主会诱发严重的肝脏疾病。肝脏具有独特的免疫系统，由不同于其他免疫器官或组织的特化细胞组成。宿主免疫反应在曼氏血吸虫感染期间发生显著变化;在早期阶段，诱导Th 1相关反应，而在晚期阶段，Th 2反应占主导地位。在这里，我们描述了独特的T细胞群诱导的小鼠肝脏在Th 1-和Th 2-阶段之间的时期，我们称之为过渡期。在这个阶段，包括T淋巴细胞在内的各种免疫细胞在肝脏中增加。CD 4 + T细胞亚群表现出独特的细胞因子产生谱，同时产生IFN-γ和IL-13或IFN-γ和IL-4。此外，IFN-γ、IL-13和IL-4三重阳性的细胞也在S.曼森氏感染的肝脏这些独特的细胞群的诱导不会发生在脾脏中，表明这是肝脏特有的现象。在显示独特细胞因子谱的单个肝CD 4 + T细胞中，T-bet和加塔-3均表达。因此，我们的研究表明，S。曼氏菌感染引发具有独特细胞因子谱的肝T细胞亚群的诱导。
During infection with Schistosoma, serious hepatic disorders are induced in the host. The liver possesses unique immune systems composed of specialized cells that differ from those of other immune competent organs or tissues. Host immune responses change dramatically during Schistosoma mansoni infection; in the early phase, Th1-related responses are induced, whereas during the late phase Th2 reactions dominate. Here, we describe unique T cell populations induced in the liver of mice during the period between Th1- and Th2-phases, which we term the transition phase. During this phase, varieties of immune cells including T lymphocytes increase in the liver. Subsets of CD4+ T cells exhibit unique cytokine production profiles, simultaneously producing both IFN-γ and IL-13 or both IFN-γ and IL-4. Furthermore, cells triply positive for IFN-γ, IL-13 and IL-4 also expand in the S. mansoni-infected liver. The induction of these unique cell populations does not occur in the spleen, indicating it is a phenomenon specific to the liver. In single hepatic CD4+ T cells showing the unique cytokine profiles, both T-bet and GATA-3 are expressed. Thus, our studies show that S. mansoni infection triggers the induction of hepatic T cell subsets with unique cytokine profiles.
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DOI：
10.1038/nrrheum.2012.58
发表时间：
2012-05-01
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/s0167-5699(99)01551-0
发表时间：
2000-01-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
Fallon, PG
通讯作者：
Fallon, PG
影响因子：
64.8
作者：
FERRICK, DA;SCHRENZEL, MD;LEPPER, H
通讯作者：
LEPPER, H
影响因子：
4.4
作者：
Fallon, PG;Richardson, EJ;McKenzie, ANJ
通讯作者：
McKenzie, ANJ
影响因子：
4
作者：
Fitzpatrick, Jennifer M.;Fuentes, Jose M.;Hesse, Matthias
通讯作者：
Hesse, Matthias