Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity.
Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity.
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DOI：
10.3390/ijms19113608
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发表时间：
2018-11-15
影响因子：
5.6
通讯作者：
Souza BSF
中科院分区：
文献类型：
--
作者：
Improta Caria AC;Nonaka CKV;Pereira CS;Soares MBP;Macambira SG;Souza BSF
MicroRNAs是一种小的非编码RNA，在转录后调节基因的表达。它们参与生理过程的调节，如对体育锻炼的适应，也参与疾病环境，如系统性动脉高血压(SAH)、2型糖尿病(T2D)和肥胖。在SAH中，microRNAs在导致肾素-血管紧张素-醛固酮系统过度激活、内皮功能障碍、炎症、增殖和平滑肌细胞表型改变以及交感神经系统过度激活的关键信号通路的调节中发挥重要作用。MicroRNAs还参与T2D中胰岛素信号和血糖水平的调节，并参与肥胖的脂代谢、脂肪形成和脂肪细胞分化，每种疾病的发病机制都有特定的microRNA信号。许多研究报道，运动训练通过降低血压、血糖水平、改善胰岛素信号和脂代谢来促进心血管疾病的益处。然而，涉及的分子机制仍然知之甚少，特别是关于microRNAs在这些过程中的参与。这篇综述旨在强调已知的与SAH、T2D和肥胖相关的microRNAs，以及它们可能通过运动训练进行的调节。
MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in the regulation of physiological processes, such as adaptation to physical exercise, and also in disease settings, such as systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2D), and obesity. In SAH, microRNAs play a significant role in the regulation of key signaling pathways that lead to the hyperactivation of the renin-angiotensin-aldosterone system, endothelial dysfunction, inflammation, proliferation, and phenotypic change in smooth muscle cells, and the hyperactivation of the sympathetic nervous system. MicroRNAs are also involved in the regulation of insulin signaling and blood glucose levels in T2D, and participate in lipid metabolism, adipogenesis, and adipocyte differentiation in obesity, with specific microRNA signatures involved in the pathogenesis of each disease. Many studies report the benefits promoted by exercise training in cardiovascular diseases by reducing blood pressure, glucose levels, and improving insulin signaling and lipid metabolism. The molecular mechanisms involved, however, remain poorly understood, especially regarding the participation of microRNAs in these processes. This review aimed to highlight microRNAs already known to be associated with SAH, T2D, and obesity, as well as their possible regulation by exercise training.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
3.3
作者：
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影响因子：
7.7
作者：
Arner E;Mejhert N;Kulyté A;Balwierz PJ;Pachkov M;Cormont M;Lorente-Cebrián S;Ehrlund A;Laurencikiene J;Hedén P;Dahlman-Wright K;Tanti JF;Hayashizaki Y;Rydén M;Dahlman I;van Nimwegen E;Daub CO;Arner P
通讯作者：
Arner P
影响因子：
12.3
作者：
Chalmers, J
通讯作者：
Chalmers, J
影响因子：
5.5
作者：
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通讯作者：
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