Novel in silico multivariate mapping of intrinsic and anticorrelated connectivity to neurocognitive functional maps supports the maturational hypothesis of ADHD.
Novel in silico multivariate mapping of intrinsic and anticorrelated connectivity to neurocognitive functional maps supports the maturational hypothesis of ADHD.
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DOI：
10.1002/hbm.24187
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发表时间：
2018-08
影响因子：
4.8
通讯作者：
Calhoun VD
中科院分区：
文献类型：
--
作者：
de Lacy N;Kodish I;Rachakonda S;Calhoun VD
从儿童期到青春期，与认知控制相关的额叶、纹状体和顶叶颞叶区域的耦合增强，以及任务正回路和任务负回路之间的反相关性增强，有助于行为的重塑。ADHD是一种常见的疾病，在青春期达到顶峰，在成年后逐渐消退，并伴有各种认知控制缺陷。ADHD的其他假设强调滞后电路改进与网络功能的分类差异。然而，考虑到所涉及的神经行为功能的多样性，量化个体回路对行为发现的贡献，以及成熟效应与分类效应的相对作用，在体内或在同一管道中使用基于任务的范式进行荟萃分析时是具有挑战性的。为了解决这个问题，我们在一个多变量模型中分析了504名年龄和性别匹配的年轻人静息状态数据中的46个正相关和反相关回路，并创建了一种新颖的计算机方法来绘制个体量化效应，以反向推断与ADHD、多巴胺和多动症相关的8种神经认知功能。我们只确定了内在连通性中与年龄和性别相关的影响，并发现患有ADHD的青少年回路的成熟细化占据了比典型发育多3 - 10倍的大脑位置，个体回路的足迹、效应大小和贡献存在很大差异。我们的分析支持ADHD的成熟假说，表明在额顶叶控制、腹侧注意、扣带回-眼、颞边缘和小脑亚网络的特定亚网络中，滞后的连接重组有助于在这种复杂情况下出现的神经认知发现。我们首次分析了ADHD的反相关连通性，并提出了探索残余和非反应性症状的新方向。
From childhood to adolescence, strengthened coupling in frontal, striatal and parieto-temporal regions associated with cognitive control, and increased anticorrelation between task-positive and task-negative circuits, subserve the reshaping of behavior. ADHD is a common condition peaking in adolescence and regressing in adulthood, with a wide variety of cognitive control deficits. Alternate hypotheses of ADHD emphasize lagging circuitry refinement versus categorical differences in network function. However, quantifying the individual circuit contributions to behavioral findings, and relative roles of maturational versus categorical effects, is challenging in vivo or in meta-analyses using task-based paradigms within the same pipeline, given the multiplicity of neurobehavioral functions implicated. To address this, we analyzed 46 positively-correlated and anticorrelated circuits in a multivariate model in resting-state data from 504 age- and gender-matched youth, and created a novel in silico method to map individual quantified effects to reverse inference maps of 8 neurocognitive functions consistently implicated in ADHD, as well as dopamine and hyperactivity. We identified only age- and gender-related effects in intrinsic connectivity, and found that maturational refinement of circuits in youth with ADHD occupied 3–10× more brain locations than in typical development, with the footprint, effect size and contribution of individual circuits varying substantially. Our analysis supports the maturational hypothesis of ADHD, suggesting lagging connectivity reorganization within specific subnetworks of fronto-parietal control, ventral attention, cingulo-opercular, temporo-limbic and cerebellar sub-networks contribute across neurocognitive findings present in this complex condition. We present the first analysis of anti-correlated connectivity in ADHD and suggest new directions for exploring residual and non-responsive symptoms.
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DOI：
10.1111/j.1532-7795.2010.00712.x
发表时间：
2011-03-01
期刊：
Journal of research on adolescence : the official journal of the Society for Research on Adolescence
影响因子：
--
作者：
Casey B;Jones RM;Somerville LH
通讯作者：
Somerville LH
影响因子：
3.7
作者：
Couvy-Duchesne B;Ebejer JL;Gillespie NA;Duffy DL;Hickie IB;Thompson PM;Martin NG;de Zubicaray GI;McMahon KL;Medland SE;Wright MJ
通讯作者：
Wright MJ
影响因子：
2.5
作者：
Ernst, Monique
通讯作者：
Ernst, Monique
影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
影响因子：
17.6
作者：
Calhoun VD;Adalı T
通讯作者：
Adalı T