Absence seizures associated with efavirenz initiation.
Absence seizures associated with efavirenz initiation.
复制标题
与开始依非韦伦相关的失神发作。
DOI:
10.1097/inf.0b013e318223b680
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发表时间:
2011
期刊:
影响因子:
--
通讯作者:
Abrams,ElaineJ
中科院分区:
文献类型:
--
作者:
Strehlau,Renate;Martens,Leigh;Coovadia,Ashraf;Dandara,Collet;Norman,Jennifer;Maisel,Julia;Kuhn,Louise;Abrams,ElaineJ
Efavirenz, used in treating pediatric human immunodeficiency virus infection, has central nervous system side effects. We report on a 5-year-old girl with perinatally acquired human immunodeficiency virus infection, presenting with new onset absence seizures after starting treatment with efavirenz. Plasma efavirenz values were above therapeutic range. The child was homozygous for the CYP2B6–516T/T genotype, which is associated with poor efavirenz clearance. Seizures abated after efavirenz discontinuation.
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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DOI:
--
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AIDS (London)
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