Real-world stress resilience is associated with the responsivity of the locus coeruleus.
Real-world stress resilience is associated with the responsivity of the locus coeruleus.
复制标题
现实世界的应力弹性与层层层的响应性有关。
DOI：
10.1038/s41467-021-22509-1
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发表时间：
2021-04-15
影响因子：
16.6
通讯作者：
Kleim B
中科院分区：
文献类型：
--
作者：
Grueschow M;Stenz N;Thörn H;Ehlert U;Breckwoldt J;Brodmann Maeder M;Exadaktylos AK;Bingisser R;Ruff CC;Kleim B
个体对压力事件的反应可能不同。在这里，我们调查的神经生物学基础的压力弹性，通过显示，神经反应的去甲肾上腺素能蓝斑（LC-NE）和相关的瞳孔反应与随后的变化，在长期的现实生活中的压力的焦虑和抑郁的措施。我们在住院医生经历紧张的急诊室实习之前的情绪冲突任务中获得了fMRI和瞳孔测量数据，这些实习被认为是焦虑和抑郁的风险因素。LC-NE冲突反应及其与杏仁核的功能耦合与应激相关的症状变化，在响应实习。瞳孔扩张（LC-NE放电的潜在标志物）也存在类似的关系。我们的研究结果提供了深入了解冲突的产生，适应和压力弹性的去甲肾上腺素能基础。每个人在如何受到压力的影响方面差异很大。在这里，作者表明，由长期的现实生活压力引发的精神病理学症状的严重程度与fMRI测量的人类脑干唤醒系统的反应性和相关的瞳孔反应有关。
Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are related to the subsequent change in measures of anxiety and depression in response to prolonged real-life stress. We acquired fMRI and pupillometry data during an emotional-conflict task in medical residents before they underwent stressful emergency-room internships known to be a risk factor for anxiety and depression. The LC-NE conflict response and its functional coupling with the amygdala was associated with stress-related symptom changes in response to the internship. A similar relationship was found for pupil-dilation, a potential marker of LC-NE firing. Our results provide insights into the noradrenergic basis of conflict generation, adaptation and stress resilience. Individuals vary considerably in how they are affected by stress. Here, the authors show that the severity of psychopathological symptoms triggered by prolonged real-life stress relate to fMRI-measured responsivity of the human brainstem arousal system and associated pupil responses.
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影响因子：
2.9
作者：
Brooks JC;Faull OK;Pattinson KT;Jenkinson M
通讯作者：
Jenkinson M
影响因子：
4.8
作者：
Costa, Vincent D.;Lang, Peter J.;Sabatinelli, Dean;Versace, Francesco;Bradley, Margaret M.
通讯作者：
Bradley, Margaret M.
影响因子：
5
作者：
Arnsten, Amy F T;Raskind, Murray A;Taylor, Fletcher B;Connor, Daniel F
通讯作者：
Connor, Daniel F
DOI：
10.1146/annurev-clinpsy-032210-104526
发表时间：
2011-01-01
影响因子：
18.4
作者：
Bonanno, George A.;Westphal, Maren;Mancini, Anthony D.
通讯作者：
Mancini, Anthony D.
DOI：
10.1017/s1355617799544020
发表时间：
1999-05-01
影响因子：
2.6
作者：
Brown, GG;Kindermann, SS;Buxton, RB
通讯作者：
Buxton, RB