Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materials.
Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materials.
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评估通过一系列个人保护设备材料对SARS-COV-2接触和划分传播的相对潜力。
DOI：
10.1038/s41598-022-20952-8
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发表时间：
2022-10-05
影响因子：
4.6
通讯作者：
Alexander, Morgan R.
中科院分区：
文献类型：
--
作者：
Xue, Xuan;Coleman, Christopher M.;Duncan, Joshua D.;Hook, Andrew L.;Ball, Jonathan K.;Alexander, Cameron;Alexander, Morgan R.
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）-2019冠状病毒病（COVID-19）的病原体-已造成全球公共卫生紧急情况。个人防护设备（PPE）是医疗保健和社区环境中防止病毒暴露的主要防御措施。但是，PPE材料的表面可能会捕获病毒，用于接触传播或通过在移除PPE、清洁或移动过程中产生的负载气溶胶传播。在这项研究中，目前的PPE材料在病毒粒子吸附材料和其抗病毒效力方面的相对功效，首次在广泛的PPE上进行了评估，包括四种聚合物手套类型，两种类型的磨砂，围裙材料，口罩，遮阳板和其他商业聚合物和产品的选择。尽管观察到病毒粒子吸附到测试材料上的差异，但现有的基于聚合物的PPE在10分钟或30分钟的接触时间内都没有导致SARS-CoV-2滴度降低10倍以上。对测试材料的润湿性和表面化学进行了分析，以研究与其表面物理化学性质的任何相关性。虽然在气流挑战下未发现润湿性与病毒截留之间的相关性，但在测试材料的ToF-SIMS数据中，m/z 101.03（+）的一个二次离子和m/z 31.98（-）、196.93（-）和394.33（+）的三个二次离子分别与病毒截留显示出正相关性和负相关性，通过PLS回归模型验证了该吸附量，表明表面化学性质对病毒粒子的吸附程度起着决定性作用。我们的研究结果概述了影响当前PPE对SARS-CoV-2传播的有效性的材料方面，并对开发新的简单聚合物基PPE以更好地保护感染提出了建议。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—the causative agent of coronavirus disease 2019 (COVID-19)—has caused a global public health emergency. Personal protective equipment (PPE) is the primary defence against viral exposure in healthcare and community settings. However, the surfaces of PPE materials may trap virus for contact transmission or through laden aerosols generated during removal of PPE, through cleaning or during movement. In this study, the relative efficacy of current PPE materials in terms of virion adsorption to materials and their antiviral potency, has been evaluated on a wide range of PPE for the first time, including four polymer glove types, two types of scrubs, apron material, a mask, visor and a selection of other commercial polymers and products. Although differences in virion adsorption to the test materials were observed, none of the existing polymer-based PPE resulted in more than tenfold reduction in the SARS-CoV-2 titre within either 10 min or 30 min contact period. The wettability and surface chemistry of the test materials were analysed to investigate any correlations with their surface physicochemical properties. While no correlation was found between wettability and viral retention under air flow challenge, one secondary ion of m/z 101.03 (+) and three secondary ions of m/z 31.98 (−), 196.93 (−) and 394.33 (+) in ToF–SIMS data of the test materials showed positive and negative correlations with the viral retention, respectively, which was identified by PLS regression model, suggesting that the surface chemistry plays a role in determining the extent of virion adsorption. Our findings outline the material aspects that influence the efficacy of current PPE against SARS-CoV-2 transmission and give suggestions on the development of novel simple polymer-based PPE for better infection protection.
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影响因子：
46.9
作者：
通讯作者：
--
影响因子：
1.7
作者：
Taylor, Michael;Urquhart, Andrew J.;Anderson, Daniel G.;Langer, Robert;Davies, Martyn C.;Alexander, Morgan R.
通讯作者：
Alexander, Morgan R.
影响因子：
4.6
作者：
Kasloff SB;Leung A;Strong JE;Funk D;Cutts T
通讯作者：
Cutts T
影响因子：
--
作者：
Coleman CM;Frieman MB
通讯作者：
Frieman MB
影响因子：
11.8
作者：
Casanova, Lisa;Alfano-Sobsey, Edie;Sobsey, Mark
通讯作者：
Sobsey, Mark