The skin is an important bulwark of acquired immunity against intestinal helminths.
The skin is an important bulwark of acquired immunity against intestinal helminths.
复制标题
DOI：
10.1084/jem.20130761
复制
发表时间：
2013-11-18
期刊：
影响因子：
--
通讯作者：
Karasuyama H
中科院分区：
文献类型：
--
作者：
Obata-Ninomiya K;Ishiwata K;Tsutsui H;Nei Y;Yoshikawa S;Kawano Y;Minegishi Y;Ohta N;Watanabe N;Kanuka H;Karasuyama H
在继发性感染期间，产生il -4的嗜碱性细胞促进巴西乳杆菌在皮肤上的捕获，这是限制感染扩散到肺部的关键过程。一旦动物经历了蠕虫感染，它们通常对随后的感染表现出更强的保护性免疫。虽然众所周知蠕虫感染会引发th2型免疫反应，但在何处以及如何执行获得性保护仍然不清楚。在这里，我们发现侵入皮肤的肠道蠕虫巴西尼波圆线虫的幼虫被皮肤浸润细胞包围，并且在第二次感染时被阻止迁移出感染的皮肤，而不是第一次感染。B细胞或IgE受体fcε - ri缺陷小鼠的皮肤捕获幼虫受损。选择性消融嗜碱性细胞，而非肥大细胞，消除了幼虫捕获，导致肺内蠕虫负荷增加，从而导致严重的肺损伤。皮肤浸润性嗜碱性细胞产生IL-4，进而促进m2型巨噬细胞的产生，导致幼虫通过精氨酸酶-1的产生被困在皮肤中。嗜碱性粒细胞对蠕虫从肠道排出没有明显的贡献。因此，这项研究揭示了一种新的获得性抗蠕虫免疫模式，在这种模式中，ige武装的嗜碱性细胞介导幼虫的皮肤捕获，从而限制了幼虫迁移引起的肺损伤。
IL-4–producing basophils promote the trapping of N. brasiliensis in the skin during secondary infection, a process critical for limiting the spread of infection to the lungs. Once animals have experienced a helminthic infection, they often show stronger protective immunity against subsequent infections. Although helminthic infections are well known to elicit Th2-type immune responses, it remains ill-defined where and how acquired protection is executed. Here we show that skin-invading larvae of the intestinal helminth Nippostrongylus brasiliensis are surrounded by skin-infiltrating cells and are prevented from migrating out of infected skin during the second but not the first infection. B cell– or IgE receptor FcεRI–deficient mice showed impaired larval trapping in the skin. Selective ablation of basophils, but not mast cells, abolished the larval trapping, leading to increased worm burden in the lung and hence severe lung injury. Skin-infiltrating basophils produced IL-4 that in turn promoted the generation of M2-type macrophages, leading to the larval trapping in the skin through arginase-1 production. Basophils had no apparent contribution to worm expulsion from the intestine. This study thus reveals a novel mode of acquired antihelminth immunity, in which IgE-armed basophils mediate skin trapping of larvae, thereby limiting lung injury caused by larval migration.
登录
查看更多内容
DOI：
10.4049/jimmunol.0902447
发表时间：
2010-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kim S;Prout M;Ramshaw H;Lopez AF;LeGros G;Min B
通讯作者：
Min B
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
32.4
作者：
Hu-Li, J;Pannetier, C;Paul, WE
通讯作者：
Paul, WE
DOI：
10.1073/pnas.1117584109
发表时间：
2012-09-11
影响因子：
11.1
作者：
Herbst, Tina;Esser, Julia;Harris, Nicola L.
通讯作者：
Harris, Nicola L.
影响因子：
82.9
作者：
通讯作者：
--