6-Shogaol promotes bone resorption and accelerates orthodontic tooth movement through the JNK-NFATc1 signaling axis.
6-Shogaol promotes bone resorption and accelerates orthodontic tooth movement through the JNK-NFATc1 signaling axis.
复制标题
DOI：
10.1007/s00774-021-01245-y
复制
发表时间：
2021-11
影响因子：
3.3
通讯作者：
Shen G
中科院分区：
文献类型：
--
作者：
Zhu X;Yuan H;Ningjuan O;Trotman CA;Van Dyke TE;Chen JJ;Shen G
Corticotomy is widely used in clinical practice to accelerate tooth movement and shorten the duration of orthodontic treatment. It is effective, but an invasive surgery is needed to induce alveolar bone osteopenia that enable rapid tooth movement. In this study, we discovered the potential of 6-shogaol as a more patient-friendly noninvasive alternative to induce transient osteopenia and accelerate tooth movement. The effects of 6-shogaol on the Bone marrow macrophages (BMM) proliferation and osteoclast differentiation, and bone resorption were determined in vitro. Sprague-Dawley rats were distributed into three groups: CON, IPinj or Localinj and euthanized at day 28. Micro-CT, histology, immunohistological and TUNEL analysis were performed to evaluate the tooth movement acceleratation effect of 6-shogaol. In vitro, 6-shogaol promotes osteoclast differentiation and functional demineralization of alveolar bone. RANKL-induced mRNA expression of osteoclastic-specific genes was significantly higher in the presence of 6-shogaol. A dose-dependent increase in the area of TRAP-positive cells was observed with 6-shogaol treatment. F-actin ring formation and increased bone resorption confirmed that osteoclasts treated with 6-shogaol were mature and functional. 6-shogaol stimulated JNK activation and NFATc1 expression during osteoclast differentiation. In vivo, 6-shogaol promotes alveolar bone transient osteopenia and accelerates orthodontic tooth movement. Alveolar bone mass was reduced, more osteoclasts were observed in bone resorption lacunae on the compression side, and the expression of RANKL and sclerostin were higher than the control group. Our results suggest that 6-shogoal accelerates tooth movement by inducing osteopenia by a mechanism similar to surgically induced bone injury.
登录
查看更多内容
影响因子：
2.5
作者：
Roscher A;Hasegawa T;Dohnke S;Ocaña-Morgner C;Amizuka N;Jessberger R;Garbe AI
通讯作者：
Garbe AI
通过生物活性磷脂对人Traak通道的选择性调节。
影响因子：
14.8
作者：
Schrecke S;Zhu Y;McCabe JW;Bartz M;Packianathan C;Zhao M;Zhou M;Russell D;Laganowsky A
通讯作者：
Laganowsky A
影响因子：
6.2
作者：
Ikeda, Fumiyo;Matsubara, Takuma;Yoneda, Toshiyuki
通讯作者：
Yoneda, Toshiyuki
影响因子：
2.8
作者：
BOGOCH, E;GSCHWEND, N;PERREN, S
通讯作者：
PERREN, S
影响因子：
3.4
作者：
Moin, Sogole;Kalajzic, Zana;Nanda, Ravindra
通讯作者：
Nanda, Ravindra