MicroRNAs in obesity, sarcopenia, and commonalities for sarcopenic obesity: a systematic review.
MicroRNAs in obesity, sarcopenia, and commonalities for sarcopenic obesity: a systematic review.
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DOI：
10.1002/jcsm.12878
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Goljanek-Whysall K
中科院分区：
文献类型：
--
作者：
Dowling L;Duseja A;Vilaca T;Walsh JS;Goljanek-Whysall K
肌肉萎缩性肥胖症是肥胖背景下肌肉减少症的一种独特病症，具有两种表型的累积健康风险。已经分别报道了肥胖和肌肉减少症患者中microRNA（miRNAs）的差异表达，并且其可能在肌肉减少性肥胖的发病机制中起作用。然而，迄今尚未对此进行探讨。本研究旨在鉴定肥胖和肌肉减少症患者血清、血浆和骨骼肌中差异表达的miRNA，以及这些疾病之间是否存在任何共性。我们在Embase和MEDLINE（PROSPERO，CRD 42020224486）上对（i）肌肉减少症或虚弱和（ii）肥胖或代谢综合征中差异表达的miRNA（倍数变化>1.5或P值<0.05）进行了系统评价。使用PubMed搜索在两种条件下通常改变的miRNA的功能和靶点，方向相同。重复数据删除后，确定了247项肥胖和42项肌肉减少症研究进行全文筛选。筛选确定了36项肥胖症和6项肌肉减少症研究供最终纳入。在肥胖症中总共鉴定了351个miRNAs，在肌肉减少症中鉴定了157个。根据样本类型，在肥胖和肌肉减少症中鉴定了55种miRNA，其中48种在血浆中发现，血清和骨骼肌中各发现一种。从纳入的10项研究中鉴定出24种miRNA在肥胖和肌肉减少症中通常以相同方向变化（血浆中22种，血清和骨骼肌中各1种）。文献检索中识别的大多数miRNA验证靶点是磷酸肌醇3-激酶/蛋白激酶B和转化生长因子-β信号通路的成员。最常见的靶点是胰岛素样生长因子1（miR-424 - 5 p、miR-483 - 3 p和miR-18 b-5 p）和SMAD家族成员（miR-483 - 3 p、miR-92 a-3 p和miR-424 - 5 p）。大多数常见变化的miRNA涉及蛋白质稳态、线粒体动力学、肌纤维类型的确定、胰岛素抵抗和脂肪形成。24种miRNA被鉴定为在肥胖症和肌肉减少症中通常失调，其功能和靶点与肌肉减少性肥胖症的发病机制有关。鉴于与肌肉减少性肥胖相关的不良健康结果，了解这种表型的发病机制有可能导致有效的筛查，监测或治疗策略。现在需要进一步的研究来确认这些miRNAs是否在患有肌肉减少性肥胖的老年人中差异表达。
Sarcopenic obesity is a distinct condition of sarcopenia in the context of obesity, with the cumulative health risks of both phenotypes. Differential expression of microRNAs (miRNAs) has been reported separately in people with obesity and sarcopenia and may play a role in the pathogenesis of sarcopenic obesity. However, this has not been explored to date. This study aimed to identify differentially expressed miRNAs reported in serum, plasma, and skeletal muscle of people with obesity and sarcopenia and whether there are any commonalities between these conditions. We performed a systematic review on Embase and MEDLINE (PROSPERO, CRD42020224486) for differentially expressed miRNAs (fold change >1.5 or P‐value <0.05) in (i) sarcopenia or frailty and (ii) obesity or metabolic syndrome. The functions and targets of miRNAs commonly changed in both conditions, in the same direction, were searched using PubMed. Following deduplication, 247 obesity and 42 sarcopenia studies were identified for full‐text screening. Screening identified 36 obesity and 6 sarcopenia studies for final inclusion. A total of 351 miRNAs were identified in obesity and 157 in sarcopenia. Fifty‐five miRNAs were identified in both obesity and sarcopenia—by sample type, 48 were found in plasma and one each in serum and skeletal muscle. Twenty‐four miRNAs were identified from 10 of the included studies as commonly changed in the same direction (22 in plasma and one each in serum and skeletal muscle) in obesity and sarcopenia. The majority of miRNA‐validated targets identified in the literature search were members of the phosphoinositide 3‐kinase/protein kinase B and transforming growth factor‐β signalling pathways. The most common targets identified were insulin‐like growth factor 1 (miR‐424‐5p, miR‐483‐3p, and miR‐18b‐5p) and members of the SMAD family (miR‐483‐3p, miR‐92a‐3p, and miR‐424‐5p). The majority of commonly changed miRNAs were involved in protein homeostasis, mitochondrial dynamics, determination of muscle fibre type, insulin resistance, and adipogenesis. Twenty‐four miRNAs were identified as commonly dysregulated in obesity and sarcopenia with functions and targets implicated in the pathogenesis of sarcopenic obesity. Given the adverse health outcomes associated with sarcopenic obesity, understanding the pathogenesis underlying this phenotype has the potential to lead to effective screening, monitoring, or treatment strategies. Further research is now required to confirm whether these miRNAs are differentially expressed in older adults with sarcopenic obesity.
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影响因子：
5.2
作者：
Butler AE;Ramachandran V;Cunningham TK;David R;Gooderham NJ;Benurwar M;Dargham SR;Hayat S;Sathyapalan T;Najafi-Shoushtari SH;Atkin SL
通讯作者：
Atkin SL
影响因子：
3.3
作者：
Baggish, Aaron L.;Park, Joseph;Chan, Stephen Y.
通讯作者：
Chan, Stephen Y.
miR-483靶向SMAD4以抑制人间充质干细胞的软骨分化。
DOI：
10.1002/jor.23552
发表时间：
2017-11
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Anderson BA;McAlinden A
通讯作者：
McAlinden A
DOI：
10.1002/jcsm.12266
发表时间：
2018-04
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Connolly M;Paul R;Farre-Garros R;Natanek SA;Bloch S;Lee J;Lorenzo JP;Patel H;Cooper C;Sayer AA;Wort SJ;Griffiths M;Polkey MI;Kemp PR
通讯作者：
Kemp PR
影响因子：
6.9
作者：
Bae, Yun-Ui;Kim, Yongjin;Kwon, Soon Hyo
通讯作者：
Kwon, Soon Hyo