Bidirectional temporal relationship between obesity and hyperinsulinemia: longitudinal observation from a Chinese cohort.
Bidirectional temporal relationship between obesity and hyperinsulinemia: longitudinal observation from a Chinese cohort.
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肥胖和高胰岛素血症之间的双向时间关系：来自中国队列的纵向观察。
DOI：
10.1136/bmjdrc-2020-002059
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发表时间：
2021-03
影响因子：
4.1
通讯作者：
Zhao J
中科院分区：
文献类型：
--
作者：
Xu C;Zhou G;Zhao M;Zhang X;Fang L;Guan Q;Zhang H;Gao L;Zhang T;Zhao J
虽然肥胖和高胰岛素血症密切相关，但其时间顺序仍不确定。本研究旨在探讨中国成年人肥胖指标与高胰岛素血症之间的时间关系模式。纵向队列包括2493名参与者（860名男性和1633名女性，随访时平均年龄为56.71岁），在2011年至2014年期间两次收集了肥胖和高胰岛素血症测量值，平均随访时间为3年。采用交叉滞后面板分析检查肥胖指标（体重指数（BMI）、腰围（WC）、臀围（HC）、腰臀比（WHR））与高胰岛素血症（胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）或β细胞功能稳态模型评估（HOMA-%β））之间的时间关系。校正年龄、性别、吸烟、饮酒和随访年限后，在BMI-胰岛素模型中，基线BMI与随访胰岛素的通径系数（β2=0.229; p<0.001）显著大于基线胰岛素与随访BMI的通径系数（β1=0.073; p<0.001）（β2>β1时p<0.001）。在WHR-胰岛素模型中，基线胰岛素与随访WHR的通径系数（β1=0.152; p<0.001）显著大于基线WHR与随访胰岛素的通径系数（β2=0.077; p<0.001）（β1>β2，p=0.007）。在WC/HC-胰岛素模型中，基线胰岛素对随访WC或HC的通径系数（β 1 s）也大于基线WC或HC对随访胰岛素的通径系数（β2s），但β 1 s和β2s之间的差异不显著。HOMA-IR或HOMA-%β的肥胖指标之间存在相似的时间模式。这些发现表明，肥胖和高胰岛素血症之间存在双向关系，腹部肥胖指标对高胰岛素血症指标比BMI更敏感。
Although obesity and hyperinsulinemia are closely intercorrelated, their temporal sequence is still uncertain. This study aims to investigate the temporal relationship patterns between obesity measures and hyperinsulinemia in Chinese adults. The longitudinal cohort consisted of 2493 participants (860 males and 1633 female, mean age 56.71 years at follow-up) for whom measurements of obesity and hyperinsulinemia measures were collected twice between 2011 and 2014, with an average follow-up time of 3 years. Cross-lagged panel analysis was used to examine the temporal relationship between obesity measures (body mass index (BMI); waist circumference (WC); hip circumference (HC); waist-to-hip ratio (WHR)) and hyperinsulinemia (insulin, homeostasis model assessment of insulin resistance (HOMA-IR), or homeostasis model assessment of beta cell function (HOMA-%β)). After the adjustment of age, sex, smoking, drinking and follow-up years, in the BMI-insulin model, the path coefficient (β2=0.229; p<0.001) of baseline BMI to follow-up insulin was significantly greater than the path coefficient (β1=0.073; p<0.001) of baseline insulin to follow-up BMI (p<0.001 for β2>β1). In the WHR-insulin model, the path coefficient (β1=0.152; p<0.001) of baseline insulin to follow-up WHR was significantly greater than the path coefficient (β2=0.077; p<0.001) of baseline WHR to follow-up insulin (p=0.007 for β1>β2). In the WC/HC-insulin model, the path coefficients of baseline insulin to follow-up WC or HC (β1s) were also greater than the path coefficients of baseline WC or HC to follow-up insulin (β2s), but the difference between β1s and β2s were not significant. The similar temporal patterns were founded between obesity measures with HOMA-IR or HOMA-%β. These findings indicate that there is a bidirectional relationship between obesity and hyperinsulinemia, and abdominal obesity measures are more sensitive to hyperinsulinemia measures than BMI.
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影响因子：
37.8
作者：
Dale CE;Fatemifar G;Palmer TM;White J;Prieto-Merino D;Zabaneh D;Engmann JEL;Shah T;Wong A;Warren HR;McLachlan S;Trompet S;Moldovan M;Morris RW;Sofat R;Kumari M;Hyppönen E;Jefferis BJ;Gaunt TR;Ben-Shlomo Y;Zhou A;Gentry-Maharaj A;Ryan A;UCLEB Consortium; METASTROKE Consortium;Mutsert R;Noordam R;Caulfield MJ;Jukema JW;Worrall BB;Munroe PB;Menon U;Power C;Kuh D;Lawlor DA;Humphries SE;Mook-Kanamori DO;Sattar N;Kivimaki M;Price JF;Davey Smith G;Dudbridge F;Hingorani AD;Holmes MV;Casas JP
通讯作者：
Casas JP
影响因子：
30.8
作者：
Fleury, C;Neverova, M;Warden, CH
通讯作者：
Warden, CH
影响因子：
22.4
作者：
ROGOSA, D
通讯作者：
ROGOSA, D
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.
DOI：
10.1096/fj.201700518r
发表时间：
2018-03
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Page MM;Skovsø S;Cen H;Chiu AP;Dionne DA;Hutchinson DF;Lim GE;Szabat M;Flibotte S;Sinha S;Nislow C;Rodrigues B;Johnson JD
通讯作者：
Johnson JD