Glycoprotein C of herpes simplex virus type 1 is essential for the virus to evade antibody-independent complement-mediated virus inactivation and lysis of virus-infected cells.
Glycoprotein C of herpes simplex virus type 1 is essential for the virus to evade antibody-independent complement-mediated virus inactivation and lysis of virus-infected cells.
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1 型单纯疱疹病毒的糖蛋白 C 对于病毒逃避不依赖于抗体的补体介导的病毒灭活和病毒感染细胞的裂解至关重要。
作者：
Y. Hidaka;Y. Sakai;Y. Toh;R. Mori
单纯疱疹病毒1型（HSV-1）的糖蛋白C（gC）是补体成分C3 b的受体。我们以前曾在三个不同的时间从复发性角膜炎患者中分离出HSV-1 gC-菌株（TN 1、TN 2和TN 3）。这些是非常罕见的分离株，因为gC被认为是体内病毒所必需的。为了确定gC是否修饰补体与无细胞病毒或病毒感染细胞的相互作用，我们构建了gC+重组病毒，其中将科斯株的完整gC基因插入到TN 1病毒基因组中。TN 1病毒被补体灭活，TN 1病毒感染的细胞被补体溶解;然而，gC+重组病毒对补体的这些作用产生了抵抗力。这些结果表明gC在保护病毒体包膜和感染细胞表面免受补体损伤中的作用。TN 1病毒可被大鼠（Wistar、WKA、F344和SD）、豚鼠（Hartley）和人的补体灭活，但不能被小鼠（C_3H、DDD和BALB/c）的补体灭活。
Glycoprotein C (gC) of herpes simplex virus type 1 (HSV-1) is a receptor for the complement component C3b. We have previously isolated HSV-1 gC- strains (TN1, TN2 and TN3) from a patient with recurrent keratitis at three different times. These are very rare isolates because gC was thought to be essential for the virus in vivo. To determine whether gC modifies the interaction of complement with cell-free virus or virus-infected cells, we constructed gC+ recombinant viruses in which the intact gC gene of strain KOS was inserted into the TN1 virus genome. TN1 virus was inactivated by complement and TN1 virus-infected cells were lysed by complement; however, gC+ recombinant viruses became resistant to these effects of complement. These results suggest a role for gC in protection of both the virion envelope and the infected cell surface against damage by complement. TN1 virus was inactivated by complement from rats (Wistar, WKA, F344 and SD), guinea-pigs (Hartley) and humans, but not by complement from mice (C3H, DDD and BALB/c), which indicates that mice seem to be inappropriate as an experimental model for the study of HSV infection in which complement factors need to be considered.
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鉴定 1 型单纯疱疹病毒 (HSV-1) 糖蛋白 gC 作为 HSV-1 特异性记忆细胞毒性 T 淋巴细胞的免疫显性抗原。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Glorioso,J;Kees,U;Kumel,G;Kirchner,H;Krammer,PH
通讯作者：
Krammer,PH
影响因子：
4.4
作者：
J. Edwards;T. Gaither;J. O’Shea;D. Rotrosen;T. Lawley;S. Wright;M. Frank;I. Green
通讯作者：
J. Edwards;T. Gaither;J. O’Shea;D. Rotrosen;T. Lawley;S. Wright;M. Frank;I. Green
DOI：
10.1073/pnas.84.12.4303
发表时间：
1987-06
影响因子：
11.1
作者：
R. Longnecker;S. Chatterjee;R. Whitley;B. Roizman
通讯作者：
R. Longnecker;S. Chatterjee;R. Whitley;B. Roizman
病毒诱导的补体激活和中性粒细胞介导的针对呼吸道合胞病毒（RSV）的细胞毒性。
影响因子：
4.6
作者：
Kaul,TN;Faden,H;Baker,R;Ogra,PL
通讯作者：
Ogra,PL
单纯疱疹病毒糖蛋白 C 从插入该病毒胸苷激酶基因的 DNA 片段中表达。
DOI：
10.1073/pnas.79.21.6612
发表时间：
1982
影响因子：
11.1
作者：
Lee,GT;Pogue-Geile,KL;Pereira,L;Spear,PG
通讯作者：
Spear,PG