The roles of cellular nanomechanics in cancer.
The roles of cellular nanomechanics in cancer.
复制标题
DOI：
10.1002/med.21329
复制
发表时间：
2015-01
影响因子：
13.3
通讯作者：
Chauhan, Subhash C.
中科院分区：
文献类型：
--
作者：
Yallapu, Murali M.;Katti, Kalpana S.;Katti, Dinesh R.;Mishra, Sanjay R.;Khan, Sheema;Jaggi, Meena;Chauhan, Subhash C.
关键词：
细胞和组织的生物力学特性可能有助于增加我们对细胞行为和疾病（如癌症）的细胞表现的理解。纳米力学特性可以提供临床翻译的疗法超越目前所采用的。纳米力学性质，通常通过原子力显微镜纳米压痕方法测量，可以识别形态变化、细胞结合力和表面粘附行为，有效区分正常细胞和癌细胞。这篇综述的目的是检查目前的研究涉及原子力显微镜/纳米压痕在测量细胞纳米力学中的一般使用；影响细胞纳米力学性能的各种因素和仪器条件；并采用纳米压痕方法区分癌细胞与正常细胞或组织。将这些基本的纳米力学特性应用到目前的临床治疗中，可能会提高癌症的诊断、治疗和预防效率，最终改变患者的生活。
The biomechanical properties of cells and tissues may be instrumental in increasing our understanding of cellular behavior and cellular manifestations of diseases such as cancer. Nanomechanical properties can offer clinical translation of therapies beyond what are currently employed. Nanomechanical properties, often measured by nanoindentation methods using atomic force microscopy, may identify morphological variations, cellular binding forces, and surface adhesion behaviors that efficiently differentiate normal cells and cancer cells. The aim of this review is to examine current research involving the general use of atomic force microscopy/nanoindentation in measuring cellular nanomechanics; various factors and instrumental conditions that influence the nanomechanical properties of cells; and implementation of nanoindentation methods to distinguish cancer cells from normal cells or tissues. Applying these fundamental nanomechanical properties to current discoveries in clinical treatment may result in greater efficiency in diagnosis, treatment, and prevention of cancer, which ultimately can change the lives of patients.
登录
查看更多内容
影响因子：
3.5
作者：
Cross SE;Jin YS;Lu QY;Rao J;Gimzewski JK
通讯作者：
Gimzewski JK
影响因子：
3.5
作者：
Cross, Sarah E.;Jin, Yu-Sheng;Gimzewski, James K.
通讯作者：
Gimzewski, James K.
影响因子：
4.9
作者：
Ho, SP;Balooch, M;Marshall, SJ
通讯作者：
Marshall, SJ
影响因子：
2.9
作者：
Hendricks, Peter;Diaz, Francisco J.;Nirmalanandhan, Victor Sanjit
通讯作者：
Nirmalanandhan, Victor Sanjit
DOI：
10.1016/j.bbrc.2010.10.034
发表时间：
2010-11-12
影响因子：
3.1
作者：
Docheva, Denitsa;Padula, Daniela;Clausen-Schaumann, Hauke
通讯作者：
Clausen-Schaumann, Hauke