Genetically-predicted prefrontal DRD4 gene expression modulates differentiated brain responses to food cues in adolescent girls and boys.
Genetically-predicted prefrontal DRD4 gene expression modulates differentiated brain responses to food cues in adolescent girls and boys.
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遗传学预测的前额叶DRD4基因表达调节青春期女孩和男孩对食物线索的不同大脑反应
DOI：
10.1038/s41598-021-02797-9
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发表时间：
2021-12-16
影响因子：
4.6
通讯作者：
Carnell S
中科院分区：
文献类型：
--
作者：
Portella AK;Papantoni A;Joseph AT;Chen L;Lee RS;Silveira PP;Dube L;Carnell S
前额叶皮层（PFC）中的多巴胺受体4（DRD 4）用于调节包括认知控制和动机在内的行为，并与行为抑制和对食物线索的反应有关。青春期是习惯性饮食行为和肥胖风险发展的敏感时期，PFC.We以前发现，影响DRD4功能或表达的遗传变异与女孩和男孩的实验室和现实世界饮食行为的测量相关。在这里，我们研究了大脑的反应，高能量密度（艾德）和低艾德的食物线索使用功能磁共振成像任务进行的饱足状态。我们使用基于基因的关联方法PrediXcan来估计个体基因型的前额叶脑区的组织特异性DRD4基因表达。在女孩中，预测的前额叶DRD 4表达较低与较高的那些人在涉及注意力和感觉运动处理的区域的分布式网络（包括额中回）中对高ED和低ED与非食物线索的激活较少，并且在涉及评价的关键区域（包括眶额皮质和腹内侧PFC）中对低ED与非食物线索的激活较少。具有较低与较高预测的前额叶DRD4表达的男性在食物线索反应中表现出最小的差异，即在顶下小叶中对高ED和低ED与非食物线索的相对更大的激活。我们的数据表明，性别特异性的影响，前额叶DRD4对大脑的食物反应在青春期，调制的分布区域相关的认知控制和动机观察到的女性青少年。
The dopamine receptor 4 (DRD4) in the prefrontal cortex (PFC) acts to modulate behaviours including cognitive control and motivation, and has been implicated in behavioral inhibition and responsivity to food cues. Adolescence is a sensitive period for the development of habitual eating behaviors and obesity risk, with potential mediation by development of the PFC. We previously found that genetic variations influencing DRD4 function or expression were associated with measures of laboratory and real-world eating behavior in girls and boys. Here we investigated brain responses to high energy–density (ED) and low-ED food cues using an fMRI task conducted in the satiated state. We used the gene-based association method PrediXcan to estimate tissue-specific DRD4 gene expression in prefrontal brain areas from individual genotypes. Among girls, those with lower vs. higher predicted prefrontal DRD4 expression showed lesser activation to high-ED and low-ED vs. non-food cues in a distributed network of regions implicated in attention and sensorimotor processing including middle frontal gyrus, and lesser activation to low-ED vs non-food cues in key regions implicated in valuation including orbitofrontal cortex and ventromedial PFC. In contrast, males with lower vs. higher predicted prefrontal DRD4 expression showed minimal differences in food cue response, namely relatively greater activation to high-ED and low-ED vs. non-food cues in the inferior parietal lobule. Our data suggest sex-specific effects of prefrontal DRD4 on brain food responsiveness in adolescence, with modulation of distributed regions relevant to cognitive control and motivation observable in female adolescents.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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Koller D
影响因子：
4.2
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DOI：
10.1080/19345747.2011.618213
发表时间：
2012-01-01
影响因子：
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作者：
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