No Evidence of Racial Differences in Endothelial Function and Exercise Blood Flow in Young, Healthy Males Following Acute Antioxidant Supplementation.
No Evidence of Racial Differences in Endothelial Function and Exercise Blood Flow in Young, Healthy Males Following Acute Antioxidant Supplementation.
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DOI：
10.1055/s-0042-119203
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发表时间：
2017-03
影响因子：
2.5
通讯作者：
Fernhall B
中科院分区：
文献类型：
--
作者：
Kappus RM;Bunsawat K;Rosenberg AJ;Fernhall B
本研究调查了急性抗氧化剂补充对9名年轻非洲裔美国人和10名白人男性（25.7 ± 1.2岁）内皮功能、运动血流量和氧化应激生物标志物的影响。我们假设，非洲裔美国男性将有较低的运动血流量和内皮细胞的反应相比，高加索男性，这些反应将得到改善后，抗氧化剂的补充。超声检查被用来测量血流在握力运动。内皮功能进行了评估，使用流量介导的扩张，并通过测量丙二醛-硫代巴比妥酸反应物质的水平来评估脂质过氧化反应。基线时，非裔美国男性的内皮功能低于白人（8.3 ± 1.7 vs. 12.2 ± 1.7%），补充抗氧化剂后，差异有所改善（10.7 ± 1.9 vs. 10.8 ± 1.8%），但相互作用不显著（p = 0.10）。补充抗氧化剂后，丙二醛-硫代巴比妥酸反应物质无显著变化。运动后肱动脉血流量和前臂血管传导性显著增加，但补充抗氧化剂后无差异。运动反应没有组间差异，补充抗氧化剂也没有组间差异，表明该队列运动期间缺乏氧化应激的影响。
This study investigated the effects of acute antioxidant supplementation on endothelial function, exercise blood flow and oxidative stress biomarkers in 9 young African American compared to 10 Caucasian males (25.7 ± 1.2 years). We hypothesized that African American males would have lower exercise blood flow and endothelial responsiveness compared to Caucasian males, and these responses would be improved following antioxidant supplementation. Ultrasonography was used to measure blood flow during handgrip exercise. Endothelial function was assessed using flow-mediated dilation, and lipid peroxidation was assessed by measuring levels of malondialdehyde-thiobarbituric acid reactive substances. African American males exhibited lower endothelial function than Caucasians at baseline (8.3 ± 1.7 vs. 12.2 ± 1.7%) and the difference was ameliorated with antioxidant supplementation (10.7 ± 1.9 % vs. 10.8 ± 1.8 %), but the interaction was not significant (p = 0.10). There were no significant changes in malondialdehyde-thiobarbituric acid reactive substances following antioxidant supplementation. There was a significant increase in brachial blood flow and forearm vascular conductance with exercise but no differences with antioxidant supplementation. There were no group differences in exercise responses and no differences with antioxidant supplementation, suggesting a lack of influence of oxidative stress during exercise in this cohort.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
5.3
作者：
Irace, C;Ceravolo, R;Gnasso, A
通讯作者：
Gnasso, A
影响因子：
8.3
作者：
Cardillo, C;Kilcoyne, CM;Panza, JA
通讯作者：
Panza, JA
影响因子：
37.8
作者：
Gokce, N;Keaney, JF;Vita, JA
通讯作者：
Vita, JA
影响因子：
1.5
作者：
Djordjevic, Dusica Z.;Cubrilo, Dejan G.;Jakovljevic, Vladimir Lj
通讯作者：
Jakovljevic, Vladimir Lj