Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation.
Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation.
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DOI：
10.1111/php.12864
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发表时间：
2018-03
影响因子：
3.3
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Hamblin MR
光生物调节(PBM)是指利用低功率密度的红光或近红外光对细胞或组织产生有益的影响。PBM疗法用于减轻疼痛、炎症和浮肿，并用于再生受损组织，如伤口、骨骼和肌腱。哺乳动物细胞吸收光的主要部位是线粒体，更具体地说，是细胞色素C氧化酶(CCO)。据推测，抑制性一氧化氮可以从CCO中解离出来，从而恢复电子传递并增加线粒体膜电位。另一种机制涉及光或热门控离子通道的激活。这篇综述将涵盖PBM中发生的氧化还原信号，并检查健康细胞和应激细胞之间的差异，在这些细胞中，PBM可能具有明显相反的作用。PBM对干细胞有显著的作用，这被认为是通过线粒体氧化还原信号来发挥作用的。PBM可以作为一种预适应方案，并可以与肌肉锻炼相互作用。光生物调节利用红光或近红外光来刺激组织的愈合和再生。线粒体和光热门控离子通道中的主要生色团是细胞色素C氧化酶。这两种机制都会导致产生能够激活转录因子的活性氧物种，并可能作为运动模拟物。
Photobiomodulation (PBM) involves the use of red or near-infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria, and more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO thus restoring electron transport and increasing mitochondrial membrane potential. Another mechanism involves activation of light or heat-gated ion channels. This review will cover the redox signaling that occurs in PBM and examine the difference between healthy and stressed cells, where PBM can have apparently opposite effects. PBM has a marked effect on stem cells, and this is proposed to operate via mitochondrial redox signaling. PBM can act as a pre-conditioning regimen, and can interact with exercise on muscles. Photobiomodulation uses red or NIR light to stimulate healing and regeneration in tissue. The primary chromophores are cytochrome c oxidase in mitochondria and light/heat gated ion channels. Both mechanisms lead to generation of reactive oxygen species that can activate transcription factors and may act as an exercise mimetic.
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影响因子：
2.9
作者：
Croasdell A;Duffney PF;Kim N;Lacy SH;Sime PJ;Phipps RP
通讯作者：
Phipps RP
影响因子：
2.5
作者：
Agrawal, Tanupriya;Gupta, Gaurav K.;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
DOI：
10.1073/pnas.1612917113
发表时间：
2016-10-11
影响因子：
11.1
作者：
Chiou, Yi-Ying;Yang, Yanyan;Sancar, Aziz
通讯作者：
Sancar, Aziz
DOI：
10.1097/med.0b013e32834afff2
发表时间：
2011-12-01
影响因子：
3.2
作者：
Anastasilakis, Athanasios D.;Polyzos, Stergios A.;Toulis, Konstantinos A.
通讯作者：
Toulis, Konstantinos A.
DOI：
10.1002/jbm.b.32897
发表时间：
2013-08-01
影响因子：
3.4
作者：
Choi, Kyuseok;Kang, Byung-Jae;Kim, Wan Hee
通讯作者：
Kim, Wan Hee