Potassium dynamics in the epileptic cortex: new insights on an old topic.
Potassium dynamics in the epileptic cortex: new insights on an old topic.
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DOI：
10.1177/1073858408317955
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Sejnowski TJ
中科院分区：
文献类型：
--
作者：
Fröhlich F;Bazhenov M;Iragui-Madoz V;Sejnowski TJ
细胞外钾浓度[K+]o的变化在癫痫中的作用尚不清楚。历史上，人们假设[K+]O是癫痫发作的致病因素。这种所谓的钾积累假说引起了大量的争论，但后来未能得到广泛的接受。然而，最近对癫痫患者和动物癫痫模型的组织病理生理学的研究揭示了[K+]o调节的畸变。包括离子浓度动力学的皮质回路的计算模型已经催化了对[K+]o在癫痫中的作用的新的兴趣。作者在这里将经典和最近对皮层[K+]o动态的见解与为下一代[K+]o研究提供起点的目标联系起来。这样的研究可能最终导致一种全新的抗癫痫药物，作用于[K+]o调节系统。
The role of changes in the extracellular potassium concentration [K+]o in epilepsy has remained unclear. Historically, it was hypothesized that [K+]o is the causal factor for epileptic seizures. This so-called potassium accumulation hypothesis led to substantial debate but subsequently failed to find wide acceptance. However, recent studies on the pathophysiology of tissue from epileptic human patients and animal epilepsy models revealed aberrations in [K+]o regulation. Computational models of cortical circuits that include ion concentration dynamics have catalyzed a renewed interest in the role of [K+]o in epilepsy. The authors here connect classical and more recent insights on [K+]o dynamics in the cortex with the goal of providing starting points for a next generation of [K+]o research. Such research may ultimately lead to an entirely new class of antiepileptic drugs that act on the [K+]o regulation system.
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