Diabetes alters mechanical properties and collagen fiber re-alignment in multiple mouse tendons.
Diabetes alters mechanical properties and collagen fiber re-alignment in multiple mouse tendons.
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DOI：
10.1007/s10439-014-1031-7
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发表时间：
2014-09
影响因子：
3.8
通讯作者：
Soslowsky, Louis J.
中科院分区：
文献类型：
--
作者：
Connizzo, Brianne K.;Bhatt, Pankti R.;Liechty, Kenneth W.;Soslowsky, Louis J.
肌腱的功能是通过其复杂的组成和层次结构将负荷从肌肉转移到骨骼，主要由I型胶原蛋白组成。最近的证据表明，II型糖尿病可能导致胶原结构的改变，如不规则的原纤维形态和密度，这可能在肌腱的机械功能中发挥作用。使用II型糖尿病的db/db小鼠模型，发现与非糖尿病组相比，糖尿病皮肤具有受损的生物力学性质。本研究的目的是使用db/db小鼠模型评估糖尿病对三种功能不同的肌腱（跟腱、冈上肌、髌骨）的生物力学、胶原纤维重新排列和生物化学的影响。结果表明，横截面积和刚度，但不是模量，在所有三个肌腱显着减少。然而，与预期相反，肌腱对载荷的反应（过渡应变、胶原纤维重新排列）发生在力学测试的早期。此外，与其他两种肌腱相比，髌腱对糖尿病的反应发生了改变，纤维重新排列没有变化，肌腱中间物质的胶原蛋白含量减少。总的来说，II型糖尿病改变了肌腱的机械性能和对负荷的动态反应。
Tendons function to transfer load from muscle to bone through their complex composition and hierarchical structure, consisting mainly of type I collagen. Recent evidence suggests that type II diabetes may cause alterations in collagen structure, such as irregular fibril morphology and density, which could play a role in the mechanical function of tendons. Using the db/db mouse model of type II diabetes, the diabetic skin was found to have impaired biomechanical properties when compared to the non-diabetic group. The purpose of this study was to assess the effect of diabetes on biomechanics, collagen fiber re-alignment, and biochemistry in three functionally different tendons (Achilles, supraspinatus, patellar) using the db/db mouse model. Results showed that cross-sectional area and stiffness, but not modulus, were significantly reduced in all three tendons. However, the tendon response to load (transition strain, collagen fiber re-alignment) occurred earlier in the mechanical test, contrary to expectations. In addition, the patellar tendon had an altered response to diabetes when compared to the other two tendons, with no changes in fiber realignment and decreased collagen content at the midsubstance of the tendon. Overall, type II diabetes alters tendon mechanical properties and the dynamic response to load.
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影响因子：
2.8
作者：
FRANK, C;MCDONALD, D;SHRIVE, N
通讯作者：
SHRIVE, N
DOI：
10.1115/1.4023234
发表时间：
2013-02-01
影响因子：
1.7
作者：
Connizzo, Brianne K.;Sarver, Joseph J.;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.
影响因子：
3.8
作者：
Elliott, DM;Robinson, PS;Soslowsky, LJ
通讯作者：
Soslowsky, LJ
影响因子：
2.4
作者：
Miller, Kristin S.;Connizzo, Brianne K.;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.
影响因子：
4.1
作者：
KENT, MJC;LIGHT, ND;BAILEY, AJ
通讯作者：
BAILEY, AJ