Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics.
Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics.
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DOI：
10.1021/la202602q
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发表时间：
2011-10-04
期刊：
影响因子：
--
通讯作者：
Vo-Dinh T
中科院分区：
文献类型：
--
作者：
Fales AM;Yuan H;Vo-Dinh T
本文报道了表面增强拉曼散射（SERS）标记金纳米恒星的合成和表征，该纳米恒星表面涂有含有亚甲基蓝光敏药物的二氧化硅外壳，用于单线态制氧。据我们所知，这是第一次报道纳米复合材料具有SERS检测和光动力治疗的单线态氧生成的综合能力。金纳米恒星在近红外（NIR）光谱区域被调整为最大吸收，并被近红外染料标记为表面增强共振拉曼散射（SERRS）。用二氧化硅涂层将光敏剂亚甲基蓝包裹在纳米颗粒周围的外壳中。在785 nm激发处观察到拉曼染料的SERS，而在633 nm激发处观察到亚甲基蓝的荧光。与不含亚甲基蓝的纳米颗粒合成相比，亚甲基蓝封装的纳米颗粒单线态氧生成显著增加。这种单线态氧生成的增加显示了激光照射对BT549乳腺癌细胞的细胞毒性作用。将SERS检测（诊断）和单线态产氧（治疗）结合到一个平台中，提供了一种潜在的治疗药物。
This paper reports the synthesis and characterization of surface-enhanced Raman scattering (SERS) label-tagged gold nanostars, coated with a silica shell containing methylene blue photosensitizing drug for singlet oxygen generation. To our knowledge, this is the first report of nanocomposites possessing a combined capability for SERS detection and singlet oxygen generation for photodynamic therapy. The gold nanostars were tuned for maximal absorption in the near infrared (NIR) spectral region and tagged with a NIR dye for surface-enhanced resonance Raman scattering (SERRS). Silica coating was used to encapsulate the photosensitizer methylene blue in a shell around the nanoparticles. Upon 785-nm excitation, SERS from the Raman dye is observed, while excitation at 633-nm shows fluorescence from the methylene blue. Methylene blue encapsulated nanoparticles show a significant increase in singlet oxygen generation as compared to nanoparticles synthesized without methylene blue. This increased singlet oxygen generation shows a cytotoxic effect on BT549 breast cancer cells upon laser irradiation. The combination of SERS detection (diagnostic) and singlet oxygen generation (therapeutic) into a single platform provides a potential theranostic agent.
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