SERS-active gold lace nanoshells with built-in hotspots.
SERS-active gold lace nanoshells with built-in hotspots.
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DOI：
10.1021/nl101946c
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发表时间：
2010-10-13
期刊：
影响因子：
10.8
通讯作者：
Kotov NA
中科院分区：
文献类型：
--
作者：
Yang M;Alvarez-Puebla R;Kim HS;Aldeanueva-Potel P;Liz-Marzán LM;Kotov NA
具有治疗和成像能力的多功能药物运载工具的开发以及细胞内过程的原位监测方法将极大地受益于一种简单的方法，即制备具有纳米级间隙的等离子体Au结构，在锋利的金属元素之间可以形成所谓的SERS热点。本文报道了平均直径约为100纳米的金花边胶囊的合成，该胶囊由3-5纳米宽的金属分支网络组成，中间间隔1-3纳米。采用生物相容性两亲性聚氨酯（pu）作为模板。所产生的金花边壳的不寻常的拓扑结构有点让人想起faberg<s:1>蛋，这可能反映了PU球的疏水和亲水结构域的网络。金花边由最初的开放式网状结构逐渐包裹PU模板发展而来。金蕾丝壳的直径是由pu在水中的大小决定的，可以通过pu的分子质量来调节。分支之间的接近性使它们成为表面增强拉曼光谱（SERS）的良好支撑，这是用1-萘乙醇在不同波长的光子激发下证明的。介绍了作为疏水药物模型的芘的装载和释放过程，以及利用SERS对其进行监测。
Development of multifunctional drug delivery vehicles with therapeutic and imaging capabilities as well as in-situ methods of monitoring of intracellular processes will greatly benefit from a simple method of preparation of plasmonic Au structures with nanometer scale gaps between sharp metallic elements where the so called SERS hot spots can be formed. Here the synthesis of gold lace capsules with average diameters ca. 100 nm made of a network of metallic branches 3–5 nm wide and separated by 1–3 nm gaps is reported. Biocompatible amphiphilic polyurethanes (PUs) were used as template for these particles. The unusual topology of the produced gold lace shells somewhat reminiscent of Fabergé eggs is likely to reflect the network of hydrophobic and hydrophilic domains of PU globules. The gold lace develops from initial open web-like structures by gradual enveloping the PU template. The diameter of gold lace shell is determined by the size of PUs in water and can be adjusted by the molecular mass of PUs. The close proximity between branches makes them excellent supports for surface enhanced Raman spectroscopy (SERS) which was demonstrated using 1-naphthalenethiol upon excitation with photons with different wavelengths. The loading and releasing of pyrene as a model of hydrophobic drugs and the use of SERS to monitor it were demonstrated.
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影响因子：
13.3
作者：
Alvarez-Puebla, Ramon A.;Liz-Marzan, Luis M.
通讯作者：
Liz-Marzan, Luis M.
影响因子：
15
作者：
Chen, SH;Wang, ZL;Carroll, DL
通讯作者：
Carroll, DL
影响因子：
15
作者：
Braun, Gary;Pavel, Ioana;Moskovits, Martin
通讯作者：
Moskovits, Martin
影响因子：
4
作者：
Kim, Kang;Huang, Sheng-Wen;Kaplan, Mariana J.
通讯作者：
Kaplan, Mariana J.
影响因子：
17.1
作者：
Jan, Edward;Byrne, Stephen J.;Kotov, Nicholas A.
通讯作者：
Kotov, Nicholas A.