Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision.
Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision.
复制标题
用于无创脑刺激的超高精度光产生聚焦超声。
DOI：
10.1038/s41377-022-01004-2
复制
发表时间：
2022-11-03
影响因子：
19.4
通讯作者：
Cheng, Ji-Xin
中科院分区：
文献类型：
--
作者：
Li, Yueming;Jiang, Ying;Lan, Lu;Ge, Xiaowei;Cheng, Ran;Zhan, Yuewei;Chen, Guo;Shi, Linli;Wang, Runyu;Zheng, Nan;Yang, Chen;Cheng, Ji-Xin
高精度神经调节是破译神经回路和治疗神经系统疾病的有力工具。目前的非侵入性神经调节方法只能提供毫米级的有限精度。在这里，我们报告了用于超高精度非侵入性脑刺激的光学聚焦超声（OFUS）。 OFUS 是由软光声垫 (SOAP) 产生的，该软光声垫是通过将蜡烛烟灰纳米颗粒嵌入弯曲的聚二甲基硅氧烷薄膜中而制成的。 SOAP 产生 15 MHz 的经颅超声聚焦，横向分辨率高达 83 µm，比传统经颅聚焦超声 (tFUS) 小两个数量级。在这里，我们展示了使用单个超声周期的体外有效 OFUS 神经刺激。我们在体内演示了对小鼠运动皮层的亚毫米经颅刺激。 0.6 mJ/cm2 的声能（比 tFUS 低四个数量级）足以成功进行 OFUS 神经刺激。 OFUS 通过提供超高精度非侵入性聚焦，为神经科学研究和疾病治疗提供了新功能。我们报告了用于非侵入性脑刺激的光学聚焦超声，其精度为 83 µm，比传统经颅聚焦超声小两个数量级。
High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases. Current non-invasive neuromodulation methods offer limited precision at the millimeter level. Here, we report optically-generated focused ultrasound (OFUS) for non-invasive brain stimulation with ultrahigh precision. OFUS is generated by a soft optoacoustic pad (SOAP) fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film. SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83 µm, which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound (tFUS). Here, we show effective OFUS neurostimulation in vitro with a single ultrasound cycle. We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo. An acoustic energy of 0.6 mJ/cm2, four orders of magnitude less than that of tFUS, is sufficient for successful OFUS neurostimulation. OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision non-invasively. We report optically-generated focused ultrasound for non-invasive brain stimulation with ultrahigh precision of 83 µm, which is two orders of magnitude smaller than that of conventional transcranial focused ultrasound.
登录
查看更多内容
影响因子：
46.9
作者：
Chen R;Gore F;Nguyen QA;Ramakrishnan C;Patel S;Kim SH;Raffiee M;Kim YS;Hsueh B;Krook-Magnusson E;Soltesz I;Deisseroth K
通讯作者：
Deisseroth K
影响因子：
2.4
作者：
Lee W;Chung YA;Jung Y;Song IU;Yoo SS
通讯作者：
Yoo SS
影响因子：
2.9
作者：
Ineichen, Christian;Shepherd, Naomi Ruth;Sueruecue, Oguzkan
通讯作者：
Sueruecue, Oguzkan
影响因子：
5.6
作者：
Boon, Paul;Vonck, Kristl;Van Roost, Dirk
通讯作者：
Van Roost, Dirk
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K