Odor identification and cognitive function in the Beaver Dam Offspring Study.
Odor identification and cognitive function in the Beaver Dam Offspring Study.
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DOI：
10.1080/13803395.2013.809701
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发表时间：
2013
影响因子：
2.2
通讯作者：
Nondahl DM
中科院分区：
文献类型：
--
作者：
Schubert CR;Cruickshanks KJ;Fischer ME;Huang GH;Klein R;Pankratz N;Zhong W;Nondahl DM
嗅觉障碍与老年人的认知障碍有关，但对中年人的嗅觉障碍和认知功能之间的联系知之甚少。在海狸坝后代研究中，对2837名参与者(21-84岁；平均年龄49岁)进行了嗅觉障碍与注意力、加工速度、执行和精神运动功能的认知功能测试之间的联系。在中年受试者(年龄35岁-)中，在多因素调整的回归模型中，气味识别测试中有嗅觉障碍的人完成连线测试(TMT-A和TMT-B)和凹槽钉板测试的时间显著长于没有嗅觉障碍的人。在整个队列中，TMT-A和TMT-B也有类似的结果，但GPB没有。在以中年为主的队列中，嗅觉障碍与认知功能测试中较差的表现有关。
Olfactory impairment is associated with cognitive impairment in older adults but less is known about the association of olfactory impairment and cognitive function in middle-aged adults. The association between olfactory impairment and cognitive function tests of attention, processing speed and executive and psychomotor function was explored in 2837 participants (21–84 years; mean age 49 years) in the Beaver Dam Offspring Study. Among middle-aged participants (aged 35–64 years), those with impairment on an odor identification test took significantly longer to complete the Trail Making Test (TMT-A and TMT-B) and the Grooved Peg Board (GPB) test, than those without olfactory impairment in regression models adjusted for multiple factors. Similar results were found for the TMT-A and TMT-B, but not the GPB, in the whole cohort. Olfactory impairment was associated with poorer performance on cognitive function tests in a primarily middle-aged cohort.
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